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Gene: H2AFY2 |
Gene summary for H2AFY2 |
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Gene information | Species | Human | Gene symbol | H2AFY2 | Gene ID | 55506 |
Gene name | macroH2A.2 histone | |
Gene Alias | H2AFY2 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024QZP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55506 | H2AFY2 | LZE2T | Human | Esophagus | ESCC | 4.16e-02 | 4.25e-01 | 0.082 |
55506 | H2AFY2 | LZE4T | Human | Esophagus | ESCC | 7.90e-03 | 1.72e-01 | 0.0811 |
55506 | H2AFY2 | LZE7T | Human | Esophagus | ESCC | 6.14e-12 | 5.23e-01 | 0.0667 |
55506 | H2AFY2 | LZE8T | Human | Esophagus | ESCC | 1.80e-08 | 2.45e-01 | 0.067 |
55506 | H2AFY2 | LZE22T | Human | Esophagus | ESCC | 4.26e-04 | 5.44e-01 | 0.068 |
55506 | H2AFY2 | LZE24T | Human | Esophagus | ESCC | 7.46e-29 | 7.29e-01 | 0.0596 |
55506 | H2AFY2 | LZE21T | Human | Esophagus | ESCC | 7.03e-07 | 3.88e-01 | 0.0655 |
55506 | H2AFY2 | P1T-E | Human | Esophagus | ESCC | 7.10e-13 | 3.41e-01 | 0.0875 |
55506 | H2AFY2 | P2T-E | Human | Esophagus | ESCC | 5.42e-79 | 1.34e+00 | 0.1177 |
55506 | H2AFY2 | P4T-E | Human | Esophagus | ESCC | 1.10e-45 | 9.10e-01 | 0.1323 |
55506 | H2AFY2 | P5T-E | Human | Esophagus | ESCC | 1.45e-15 | 3.21e-01 | 0.1327 |
55506 | H2AFY2 | P8T-E | Human | Esophagus | ESCC | 2.82e-28 | 4.84e-01 | 0.0889 |
55506 | H2AFY2 | P9T-E | Human | Esophagus | ESCC | 6.73e-06 | 1.28e-01 | 0.1131 |
55506 | H2AFY2 | P10T-E | Human | Esophagus | ESCC | 1.89e-42 | 6.67e-01 | 0.116 |
55506 | H2AFY2 | P11T-E | Human | Esophagus | ESCC | 1.84e-10 | 4.74e-01 | 0.1426 |
55506 | H2AFY2 | P12T-E | Human | Esophagus | ESCC | 8.28e-50 | 8.93e-01 | 0.1122 |
55506 | H2AFY2 | P15T-E | Human | Esophagus | ESCC | 1.07e-38 | 8.46e-01 | 0.1149 |
55506 | H2AFY2 | P16T-E | Human | Esophagus | ESCC | 5.29e-48 | 8.51e-01 | 0.1153 |
55506 | H2AFY2 | P17T-E | Human | Esophagus | ESCC | 1.02e-05 | 3.74e-01 | 0.1278 |
55506 | H2AFY2 | P20T-E | Human | Esophagus | ESCC | 5.69e-27 | 6.39e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
H2AFY2 | SNV | Missense_Mutation | novel | c.745C>T | p.Arg249Cys | p.R249C | Q9P0M6 | protein_coding | deleterious(0.02) | probably_damaging(0.934) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
H2AFY2 | SNV | Missense_Mutation | c.11N>A | p.Arg4Gln | p.R4Q | Q9P0M6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
H2AFY2 | insertion | In_Frame_Ins | novel | c.88_89insCAT | p.Arg30delinsProCys | p.R30delinsPC | Q9P0M6 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
H2AFY2 | insertion | Nonsense_Mutation | novel | c.90_91insTCAGGATGATTCTTACATTTAGG | p.Tyr31SerfsTer3 | p.Y31Sfs*3 | Q9P0M6 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
H2AFY2 | SNV | Missense_Mutation | rs762665495 | c.805N>A | p.Ala269Thr | p.A269T | Q9P0M6 | protein_coding | tolerated(0.09) | benign(0.437) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
H2AFY2 | SNV | Missense_Mutation | rs762910839 | c.925N>A | p.Val309Ile | p.V309I | Q9P0M6 | protein_coding | tolerated(0.63) | probably_damaging(0.944) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
H2AFY2 | SNV | Missense_Mutation | novel | c.815N>G | p.Phe272Cys | p.F272C | Q9P0M6 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
H2AFY2 | SNV | Missense_Mutation | c.520A>T | p.Thr174Ser | p.T174S | Q9P0M6 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
H2AFY2 | SNV | Missense_Mutation | novel | c.209N>G | p.Asp70Gly | p.D70G | Q9P0M6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
H2AFY2 | SNV | Missense_Mutation | c.824A>T | p.His275Leu | p.H275L | Q9P0M6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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