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Gene: GNL2 |
Gene summary for GNL2 |
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Gene information | Species | Human | Gene symbol | GNL2 | Gene ID | 29889 |
Gene name | G protein nucleolar 2 | |
Gene Alias | HUMAUANTIG | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q13823 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29889 | GNL2 | LZE2T | Human | Esophagus | ESCC | 2.43e-02 | 1.31e-01 | 0.082 |
29889 | GNL2 | LZE4T | Human | Esophagus | ESCC | 6.04e-12 | 9.51e-02 | 0.0811 |
29889 | GNL2 | LZE7T | Human | Esophagus | ESCC | 1.69e-06 | 4.54e-01 | 0.0667 |
29889 | GNL2 | LZE8T | Human | Esophagus | ESCC | 4.67e-11 | 2.02e-01 | 0.067 |
29889 | GNL2 | LZE20T | Human | Esophagus | ESCC | 1.81e-06 | 1.10e-01 | 0.0662 |
29889 | GNL2 | LZE22T | Human | Esophagus | ESCC | 6.32e-03 | 1.31e-01 | 0.068 |
29889 | GNL2 | LZE24T | Human | Esophagus | ESCC | 6.88e-14 | 3.40e-01 | 0.0596 |
29889 | GNL2 | LZE6T | Human | Esophagus | ESCC | 6.62e-04 | 1.51e-01 | 0.0845 |
29889 | GNL2 | P1T-E | Human | Esophagus | ESCC | 1.38e-09 | 3.54e-01 | 0.0875 |
29889 | GNL2 | P2T-E | Human | Esophagus | ESCC | 8.08e-26 | 5.78e-01 | 0.1177 |
29889 | GNL2 | P4T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.06e-01 | 0.1323 |
29889 | GNL2 | P5T-E | Human | Esophagus | ESCC | 2.74e-19 | 3.01e-01 | 0.1327 |
29889 | GNL2 | P8T-E | Human | Esophagus | ESCC | 7.25e-12 | 1.73e-01 | 0.0889 |
29889 | GNL2 | P9T-E | Human | Esophagus | ESCC | 2.71e-11 | 8.90e-02 | 0.1131 |
29889 | GNL2 | P10T-E | Human | Esophagus | ESCC | 1.87e-17 | 3.75e-01 | 0.116 |
29889 | GNL2 | P11T-E | Human | Esophagus | ESCC | 8.44e-10 | 5.86e-01 | 0.1426 |
29889 | GNL2 | P12T-E | Human | Esophagus | ESCC | 4.78e-16 | 2.87e-01 | 0.1122 |
29889 | GNL2 | P15T-E | Human | Esophagus | ESCC | 1.28e-25 | 4.26e-01 | 0.1149 |
29889 | GNL2 | P16T-E | Human | Esophagus | ESCC | 4.16e-23 | 2.54e-01 | 0.1153 |
29889 | GNL2 | P17T-E | Human | Esophagus | ESCC | 3.97e-08 | 4.72e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNL2 | SNV | Missense_Mutation | c.1545C>G | p.His515Gln | p.H515Q | Q13823 | protein_coding | tolerated(0.69) | benign(0) | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
GNL2 | SNV | Missense_Mutation | c.1359G>T | p.Arg453Ser | p.R453S | Q13823 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
GNL2 | SNV | Missense_Mutation | novel | c.991N>T | p.Arg331Cys | p.R331C | Q13823 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNL2 | SNV | Missense_Mutation | c.389T>G | p.Leu130Trp | p.L130W | Q13823 | protein_coding | deleterious(0) | benign(0.131) | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GNL2 | SNV | Missense_Mutation | c.1640N>C | p.Leu547Pro | p.L547P | Q13823 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
GNL2 | insertion | Frame_Shift_Ins | novel | c.643_644insCAAGGGAGCATTCATTCAGCTTCTGCGGCAGTTTGGA | p.Asp215AlafsTer23 | p.D215Afs*23 | Q13823 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GNL2 | SNV | Missense_Mutation | rs374278862 | c.2090N>A | p.Arg697His | p.R697H | Q13823 | protein_coding | tolerated(0.32) | probably_damaging(0.998) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GNL2 | SNV | Missense_Mutation | c.1106C>G | p.Ser369Cys | p.S369C | Q13823 | protein_coding | deleterious(0.04) | probably_damaging(0.99) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GNL2 | SNV | Missense_Mutation | rs140969125 | c.96G>A | p.Met32Ile | p.M32I | Q13823 | protein_coding | tolerated(0.16) | possibly_damaging(0.459) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GNL2 | SNV | Missense_Mutation | c.1868G>T | p.Arg623Ile | p.R623I | Q13823 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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