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Gene: FOXA3 |
Gene summary for FOXA3 |
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Gene information | Species | Human | Gene symbol | FOXA3 | Gene ID | 3171 |
Gene name | forkhead box A3 | |
Gene Alias | FKHH3 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R0R3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3171 | FOXA3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.09e-06 | 2.10e-01 | 0.0155 |
3171 | FOXA3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-06 | 2.90e-01 | -0.1808 |
3171 | FOXA3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.26e-02 | 3.15e-01 | 0.0216 |
3171 | FOXA3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.43e-06 | 3.28e-01 | -0.0811 |
3171 | FOXA3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.19e-10 | 3.87e-01 | -0.1088 |
3171 | FOXA3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.75e-08 | 2.95e-01 | -0.1954 |
3171 | FOXA3 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.63e-05 | 9.03e-01 | -0.2602 |
3171 | FOXA3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.66e-06 | 1.04e+00 | -0.2196 |
3171 | FOXA3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.30e-14 | 5.98e-01 | -0.1207 |
3171 | FOXA3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.74e-05 | 3.80e-01 | -0.1526 |
3171 | FOXA3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.38e-26 | 6.69e-01 | -0.1464 |
3171 | FOXA3 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.48e-10 | 3.89e-01 | -0.1001 |
3171 | FOXA3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.23e-14 | 5.33e-01 | -0.059 |
3171 | FOXA3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.01e-04 | 3.81e-01 | -0.0842 |
3171 | FOXA3 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.01e-08 | 2.72e-01 | 0.096 |
3171 | FOXA3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.01e-05 | 5.67e-01 | 0.0451 |
3171 | FOXA3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.76e-04 | 4.19e-01 | 0.0528 |
3171 | FOXA3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.04e-05 | 3.30e-01 | -0.0177 |
3171 | FOXA3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.23e-05 | 3.14e-01 | 0.0338 |
3171 | FOXA3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.01e-21 | 5.38e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0042593 | Colorectum | AD | glucose homeostasis | 83/3918 | 258/18723 | 1.44e-05 | 3.11e-04 | 83 |
GO:0001678 | Colorectum | AD | cellular glucose homeostasis | 60/3918 | 172/18723 | 1.49e-05 | 3.18e-04 | 60 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00488721 | Colorectum | SER | homeostasis of number of cells | 65/2897 | 272/18723 | 1.70e-04 | 3.19e-03 | 65 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00425941 | Colorectum | SER | response to starvation | 47/2897 | 197/18723 | 1.31e-03 | 1.45e-02 | 47 |
GO:00714961 | Colorectum | SER | cellular response to external stimulus | 70/2897 | 320/18723 | 1.40e-03 | 1.53e-02 | 70 |
GO:00092671 | Colorectum | SER | cellular response to starvation | 38/2897 | 156/18723 | 2.45e-03 | 2.32e-02 | 38 |
GO:00425931 | Colorectum | SER | glucose homeostasis | 57/2897 | 258/18723 | 2.92e-03 | 2.59e-02 | 57 |
GO:00335001 | Colorectum | SER | carbohydrate homeostasis | 57/2897 | 259/18723 | 3.20e-03 | 2.76e-02 | 57 |
GO:00316681 | Colorectum | SER | cellular response to extracellular stimulus | 54/2897 | 246/18723 | 4.26e-03 | 3.45e-02 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXA3 | SNV | Missense_Mutation | novel | c.849N>A | p.Phe283Leu | p.F283L | P55318 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXA3 | SNV | Missense_Mutation | rs200491833 | c.887C>T | p.Ala296Val | p.A296V | P55318 | protein_coding | tolerated(0.08) | benign(0) | TCGA-C8-A278-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
FOXA3 | SNV | Missense_Mutation | novel | c.400N>T | p.Pro134Ser | p.P134S | P55318 | protein_coding | tolerated(0.13) | benign(0.07) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FOXA3 | SNV | Missense_Mutation | rs769113907 | c.623N>A | p.Arg208His | p.R208H | P55318 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FOXA3 | SNV | Missense_Mutation | c.269C>T | p.Ser90Phe | p.S90F | P55318 | protein_coding | tolerated(0.3) | benign(0.185) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FOXA3 | SNV | Missense_Mutation | c.143N>G | p.Ser48Cys | p.S48C | P55318 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FOXA3 | SNV | Missense_Mutation | novel | c.775N>A | p.Glu259Lys | p.E259K | P55318 | protein_coding | tolerated(0.63) | benign(0.191) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
FOXA3 | deletion | Frame_Shift_Del | novel | c.496delN | p.Arg166AlafsTer54 | p.R166Afs*54 | P55318 | protein_coding | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
FOXA3 | SNV | Missense_Mutation | c.280N>A | p.Ala94Thr | p.A94T | P55318 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FOXA3 | SNV | Missense_Mutation | rs764817302 | c.697N>A | p.Gly233Arg | p.G233R | P55318 | protein_coding | deleterious(0.04) | benign(0.051) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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