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Gene: FGGY |
Gene summary for FGGY |
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Gene information | Species | Human | Gene symbol | FGGY | Gene ID | 55277 |
Gene name | FGGY carbohydrate kinase domain containing | |
Gene Alias | FGGY | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q96C11 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55277 | FGGY | CCI_1 | Human | Cervix | CC | 1.71e-02 | 8.46e-01 | 0.528 |
55277 | FGGY | CCI_3 | Human | Cervix | CC | 3.48e-05 | 5.20e-01 | 0.516 |
55277 | FGGY | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.79e-20 | -6.36e-01 | 0.0155 |
55277 | FGGY | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.63e-07 | -5.50e-01 | -0.1808 |
55277 | FGGY | HTA11_78_2000001011 | Human | Colorectum | AD | 3.75e-05 | -5.15e-01 | -0.1088 |
55277 | FGGY | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.17e-02 | -8.01e-01 | -0.2196 |
55277 | FGGY | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.74e-11 | -7.56e-01 | -0.1207 |
55277 | FGGY | HTA11_696_2000001011 | Human | Colorectum | AD | 8.13e-03 | -4.32e-01 | -0.1464 |
55277 | FGGY | HTA11_866_2000001011 | Human | Colorectum | AD | 4.35e-03 | -3.87e-01 | -0.1001 |
55277 | FGGY | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.97e-05 | -7.76e-01 | -0.2061 |
55277 | FGGY | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.46e-05 | -7.25e-01 | -0.0179 |
55277 | FGGY | HTA11_866_3004761011 | Human | Colorectum | AD | 5.03e-04 | -3.89e-01 | 0.096 |
55277 | FGGY | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.48e-04 | -6.86e-01 | 0.0528 |
55277 | FGGY | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.24e-07 | -4.26e-01 | 0.294 |
55277 | FGGY | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.95e-04 | 1.07e+00 | 0.3487 |
55277 | FGGY | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.01e-04 | -4.03e-01 | 0.3859 |
55277 | FGGY | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.34e-03 | -5.77e-01 | 0.2585 |
55277 | FGGY | F007 | Human | Colorectum | FAP | 3.99e-03 | 2.45e-01 | 0.1176 |
55277 | FGGY | A002-C-010 | Human | Colorectum | FAP | 3.61e-04 | 1.30e-01 | 0.242 |
55277 | FGGY | A015-C-203 | Human | Colorectum | FAP | 7.87e-28 | 1.84e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:00059961 | Colorectum | SER | monosaccharide metabolic process | 59/2897 | 257/18723 | 9.65e-04 | 1.15e-02 | 59 |
GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
GO:00059962 | Colorectum | MSS | monosaccharide metabolic process | 66/3467 | 257/18723 | 2.61e-03 | 2.06e-02 | 66 |
GO:00602493 | Colorectum | MSI-H | anatomical structure homeostasis | 38/1319 | 314/18723 | 7.73e-04 | 1.44e-02 | 38 |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00059963 | Colorectum | FAP | monosaccharide metabolic process | 59/2622 | 257/18723 | 6.79e-05 | 1.28e-03 | 59 |
GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
GO:00442622 | Colorectum | CRC | cellular carbohydrate metabolic process | 49/2078 | 283/18723 | 1.06e-03 | 1.24e-02 | 49 |
GO:00059965 | Liver | NAFLD | monosaccharide metabolic process | 53/1882 | 257/18723 | 2.89e-07 | 1.92e-05 | 53 |
GO:00442623 | Liver | NAFLD | cellular carbohydrate metabolic process | 55/1882 | 283/18723 | 1.27e-06 | 6.01e-05 | 55 |
GO:000599612 | Liver | Cirrhotic | monosaccharide metabolic process | 104/4634 | 257/18723 | 1.74e-08 | 6.32e-07 | 104 |
GO:004426211 | Liver | Cirrhotic | cellular carbohydrate metabolic process | 97/4634 | 283/18723 | 1.89e-04 | 1.76e-03 | 97 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:004426221 | Liver | HCC | cellular carbohydrate metabolic process | 153/7958 | 283/18723 | 5.27e-05 | 5.00e-04 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGGY | SNV | Missense_Mutation | c.597N>C | p.Glu199Asp | p.E199D | Q96C11 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FGGY | SNV | Missense_Mutation | c.1522N>G | p.Ser508Ala | p.S508A | Q96C11 | protein_coding | tolerated(0.49) | benign(0.101) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
FGGY | SNV | Missense_Mutation | c.569N>C | p.Leu190Pro | p.L190P | Q96C11 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FGGY | SNV | Missense_Mutation | rs773705363 | c.166G>A | p.Glu56Lys | p.E56K | Q96C11 | protein_coding | tolerated(0.09) | benign(0.063) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FGGY | SNV | Missense_Mutation | c.35A>G | p.Tyr12Cys | p.Y12C | Q96C11 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
FGGY | SNV | Missense_Mutation | rs747128652 | c.1247N>T | p.Pro416Leu | p.P416L | Q96C11 | protein_coding | tolerated_low_confidence(0.27) | benign(0.007) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
FGGY | SNV | Missense_Mutation | novel | c.1250N>A | p.Ala417Asp | p.A417D | Q96C11 | protein_coding | tolerated_low_confidence(0.65) | benign(0.367) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FGGY | SNV | Missense_Mutation | rs531685698 | c.326N>A | p.Arg109Gln | p.R109Q | Q96C11 | protein_coding | tolerated(0.62) | benign(0.045) | TCGA-DM-A0XD-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FGGY | SNV | Missense_Mutation | c.940N>T | p.Gly314Trp | p.G314W | Q96C11 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6808-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FGGY | SNV | Missense_Mutation | c.449T>G | p.Leu150Arg | p.L150R | Q96C11 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AH-6643-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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