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Gene: FAM120AOS |
Gene summary for FAM120AOS |
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Gene information | Species | Human | Gene symbol | FAM120AOS | Gene ID | 158293 |
Gene name | family with sequence similarity 120A opposite strand | |
Gene Alias | C9orf10OS | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | E9PCY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158293 | FAM120AOS | HTA11_347_2000001011 | Human | Colorectum | AD | 8.73e-09 | 3.73e-01 | -0.1954 |
158293 | FAM120AOS | A002-C-205 | Human | Colorectum | FAP | 1.35e-02 | -1.52e-01 | -0.1236 |
158293 | FAM120AOS | A015-C-006 | Human | Colorectum | FAP | 2.92e-02 | -1.67e-01 | -0.0994 |
158293 | FAM120AOS | A015-C-104 | Human | Colorectum | FAP | 8.58e-03 | -1.53e-01 | -0.1899 |
158293 | FAM120AOS | A002-C-116 | Human | Colorectum | FAP | 7.66e-03 | -1.38e-01 | -0.0452 |
158293 | FAM120AOS | LZE2T | Human | Esophagus | ESCC | 8.19e-04 | 4.69e-01 | 0.082 |
158293 | FAM120AOS | LZE4T | Human | Esophagus | ESCC | 4.10e-15 | 4.22e-01 | 0.0811 |
158293 | FAM120AOS | LZE5T | Human | Esophagus | ESCC | 2.77e-08 | 4.22e-01 | 0.0514 |
158293 | FAM120AOS | LZE7T | Human | Esophagus | ESCC | 4.55e-04 | 3.22e-01 | 0.0667 |
158293 | FAM120AOS | LZE8T | Human | Esophagus | ESCC | 4.18e-04 | 2.14e-01 | 0.067 |
158293 | FAM120AOS | LZE22T | Human | Esophagus | ESCC | 4.65e-04 | 3.22e-01 | 0.068 |
158293 | FAM120AOS | LZE24T | Human | Esophagus | ESCC | 2.77e-32 | 9.57e-01 | 0.0596 |
158293 | FAM120AOS | LZE21T | Human | Esophagus | ESCC | 1.28e-06 | 5.82e-01 | 0.0655 |
158293 | FAM120AOS | LZE6T | Human | Esophagus | ESCC | 7.83e-06 | 3.45e-01 | 0.0845 |
158293 | FAM120AOS | P1T-E | Human | Esophagus | ESCC | 1.23e-09 | 5.35e-01 | 0.0875 |
158293 | FAM120AOS | P2T-E | Human | Esophagus | ESCC | 1.09e-42 | 9.10e-01 | 0.1177 |
158293 | FAM120AOS | P4T-E | Human | Esophagus | ESCC | 8.95e-30 | 6.75e-01 | 0.1323 |
158293 | FAM120AOS | P5T-E | Human | Esophagus | ESCC | 1.88e-12 | 2.61e-01 | 0.1327 |
158293 | FAM120AOS | P8T-E | Human | Esophagus | ESCC | 6.39e-23 | 3.68e-01 | 0.0889 |
158293 | FAM120AOS | P9T-E | Human | Esophagus | ESCC | 3.83e-18 | 4.34e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM120AOS | SNV | Missense_Mutation | novel | c.608N>T | p.Gly203Val | p.G203V | Q5T036 | protein_coding | tolerated_low_confidence(0.34) | benign(0.007) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAM120AOS | SNV | Missense_Mutation | novel | c.640G>A | p.Ala214Thr | p.A214T | Q5T036 | protein_coding | deleterious_low_confidence(0.05) | benign(0.001) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM120AOS | SNV | Missense_Mutation | novel | c.728N>A | p.Thr243Asn | p.T243N | Q5T036 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
FAM120AOS | SNV | Missense_Mutation | c.736N>T | p.Pro246Ser | p.P246S | Q5T036 | protein_coding | deleterious_low_confidence(0) | benign(0.02) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
FAM120AOS | SNV | Missense_Mutation | c.311N>A | p.Pro104His | p.P104H | Q5T036 | protein_coding | deleterious_low_confidence(0.01) | benign(0.11) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
FAM120AOS | SNV | Missense_Mutation | novel | c.597G>T | p.Gln199His | p.Q199H | Q5T036 | protein_coding | deleterious_low_confidence(0) | benign(0.146) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM120AOS | SNV | Missense_Mutation | novel | c.387N>C | p.Gln129His | p.Q129H | Q5T036 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.522) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FAM120AOS | SNV | Missense_Mutation | novel | c.83T>C | p.Val28Ala | p.V28A | Q5T036 | protein_coding | deleterious_low_confidence(0) | benign(0.235) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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