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Gene: ELF3 |
Gene summary for ELF3 |
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Gene information | Species | Human | Gene symbol | ELF3 | Gene ID | 1999 |
Gene name | E74 like ETS transcription factor 3 | |
Gene Alias | EPR-1 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | A0A024R974 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1999 | ELF3 | GSM4909281 | Human | Breast | IDC | 2.78e-05 | -3.36e-01 | 0.21 |
1999 | ELF3 | GSM4909282 | Human | Breast | IDC | 2.97e-05 | 2.69e-01 | -0.0288 |
1999 | ELF3 | GSM4909286 | Human | Breast | IDC | 1.26e-03 | 1.29e-01 | 0.1081 |
1999 | ELF3 | GSM4909288 | Human | Breast | IDC | 1.35e-05 | -6.26e-01 | 0.0988 |
1999 | ELF3 | GSM4909290 | Human | Breast | IDC | 3.82e-14 | -6.31e-01 | 0.2096 |
1999 | ELF3 | GSM4909294 | Human | Breast | IDC | 2.45e-15 | -5.26e-01 | 0.2022 |
1999 | ELF3 | GSM4909296 | Human | Breast | IDC | 1.08e-03 | -1.67e-01 | 0.1524 |
1999 | ELF3 | GSM4909297 | Human | Breast | IDC | 2.19e-09 | -2.48e-01 | 0.1517 |
1999 | ELF3 | GSM4909299 | Human | Breast | IDC | 3.80e-05 | 2.76e-01 | 0.035 |
1999 | ELF3 | GSM4909300 | Human | Breast | IDC | 4.72e-04 | 4.84e-01 | 0.0334 |
1999 | ELF3 | GSM4909301 | Human | Breast | IDC | 6.50e-24 | 4.77e-01 | 0.1577 |
1999 | ELF3 | GSM4909304 | Human | Breast | IDC | 6.89e-13 | -5.49e-01 | 0.1636 |
1999 | ELF3 | GSM4909306 | Human | Breast | IDC | 1.43e-13 | 4.44e-01 | 0.1564 |
1999 | ELF3 | GSM4909311 | Human | Breast | IDC | 4.11e-37 | -6.21e-01 | 0.1534 |
1999 | ELF3 | GSM4909312 | Human | Breast | IDC | 1.33e-03 | -2.43e-01 | 0.1552 |
1999 | ELF3 | GSM4909313 | Human | Breast | IDC | 1.18e-13 | 5.23e-01 | 0.0391 |
1999 | ELF3 | GSM4909315 | Human | Breast | IDC | 5.76e-26 | -7.68e-01 | 0.21 |
1999 | ELF3 | GSM4909316 | Human | Breast | IDC | 6.89e-13 | -8.66e-01 | 0.21 |
1999 | ELF3 | GSM4909319 | Human | Breast | IDC | 2.49e-45 | -6.45e-02 | 0.1563 |
1999 | ELF3 | GSM4909321 | Human | Breast | IDC | 1.26e-48 | 6.88e-01 | 0.1559 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00017017 | Breast | Precancer | in utero embryonic development | 35/1080 | 367/18723 | 2.47e-03 | 2.27e-02 | 35 |
GO:00308796 | Breast | Precancer | mammary gland development | 16/1080 | 137/18723 | 5.59e-03 | 4.07e-02 | 16 |
GO:004873214 | Breast | IDC | gland development | 64/1434 | 436/18723 | 3.47e-07 | 1.74e-05 | 64 |
GO:003087911 | Breast | IDC | mammary gland development | 23/1434 | 137/18723 | 2.87e-04 | 4.37e-03 | 23 |
GO:00226127 | Breast | IDC | gland morphogenesis | 20/1434 | 118/18723 | 6.13e-04 | 7.69e-03 | 20 |
GO:000170113 | Breast | IDC | in utero embryonic development | 42/1434 | 367/18723 | 5.85e-03 | 4.24e-02 | 42 |
GO:004873223 | Breast | DCIS | gland development | 60/1390 | 436/18723 | 2.50e-06 | 8.74e-05 | 60 |
GO:003087921 | Breast | DCIS | mammary gland development | 22/1390 | 137/18723 | 4.74e-04 | 6.24e-03 | 22 |
GO:002261211 | Breast | DCIS | gland morphogenesis | 18/1390 | 118/18723 | 2.68e-03 | 2.36e-02 | 18 |
GO:000170122 | Breast | DCIS | in utero embryonic development | 41/1390 | 367/18723 | 5.74e-03 | 4.13e-02 | 41 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00487712 | Cervix | CC | tissue remodeling | 34/2311 | 175/18723 | 4.68e-03 | 2.82e-02 | 34 |
GO:00308797 | Cervix | CC | mammary gland development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:0030198 | Cervix | CC | extracellular matrix organization | 52/2311 | 301/18723 | 7.43e-03 | 3.98e-02 | 52 |
GO:0043062 | Cervix | CC | extracellular structure organization | 52/2311 | 302/18723 | 7.92e-03 | 4.17e-02 | 52 |
GO:0045229 | Cervix | CC | external encapsulating structure organization | 52/2311 | 304/18723 | 9.00e-03 | 4.57e-02 | 52 |
GO:00226128 | Cervix | CC | gland morphogenesis | 24/2311 | 118/18723 | 9.01e-03 | 4.57e-02 | 24 |
GO:004873215 | Cervix | N_HPV | gland development | 25/534 | 436/18723 | 7.93e-04 | 9.90e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ELF3 | MEGA | Liver | Healthy | FXYD2,LGALS4,AC090498.1, etc. | 3.80e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELF3 | SNV | Missense_Mutation | c.22N>G | p.Ser8Gly | p.S8G | P78545 | protein_coding | tolerated(0.15) | benign(0.034) | TCGA-E2-A15R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ELF3 | SNV | Missense_Mutation | rs750329636 | c.281N>A | p.Arg94Gln | p.R94Q | P78545 | protein_coding | tolerated(0.31) | benign(0.013) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ELF3 | SNV | Missense_Mutation | c.463G>A | p.Asp155Asn | p.D155N | P78545 | protein_coding | tolerated(0.14) | benign(0.244) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ELF3 | SNV | Missense_Mutation | c.752G>A | p.Arg251Gln | p.R251Q | P78545 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ELF3 | SNV | Missense_Mutation | rs745722163 | c.203N>T | p.Ser68Leu | p.S68L | P78545 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ELF3 | SNV | Missense_Mutation | c.1087N>A | p.Glu363Lys | p.E363K | P78545 | protein_coding | tolerated(0.17) | benign(0.306) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ELF3 | SNV | Missense_Mutation | c.198C>G | p.Phe66Leu | p.F66L | P78545 | protein_coding | tolerated(0.66) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ELF3 | SNV | Missense_Mutation | c.163N>A | p.Glu55Lys | p.E55K | P78545 | protein_coding | tolerated(0.25) | benign(0.197) | TCGA-4N-A93T-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
ELF3 | SNV | Missense_Mutation | novel | c.473N>G | p.Pro158Arg | p.P158R | P78545 | protein_coding | tolerated(0.07) | benign(0.157) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
ELF3 | SNV | Missense_Mutation | novel | c.440G>T | p.Gly147Val | p.G147V | P78545 | protein_coding | tolerated(0.41) | benign(0.034) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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