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Gene: DSCR8 |
Gene summary for DSCR8 |
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Gene information | Species | Human | Gene symbol | DSCR8 | Gene ID | 84677 |
Gene name | Down syndrome critical region 8 | |
Gene Alias | C21orf65 | |
Cytomap | 21q22.13 | |
Gene Type | ncRNA | GO ID | GO:0008150 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84677 | DSCR8 | S014 | Human | Liver | HCC | 4.34e-21 | 5.67e-01 | 0.2254 |
84677 | DSCR8 | S015 | Human | Liver | HCC | 6.83e-29 | 7.94e-01 | 0.2375 |
84677 | DSCR8 | S016 | Human | Liver | HCC | 6.13e-33 | 7.09e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DSCR8 | SNV | Missense_Mutation | novel | c.267G>T | p.Gln89His | p.Q89H | Q96T75 | protein_coding | deleterious_low_confidence(0) | benign(0.398) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DSCR8 | SNV | Missense_Mutation | novel | c.43C>A | p.Leu15Ile | p.L15I | Q96T75 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.578) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DSCR8 | SNV | Missense_Mutation | novel | c.289N>T | p.Pro97Ser | p.P97S | Q96T75 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.81) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DSCR8 | SNV | Missense_Mutation | novel | c.290C>T | p.Pro97Leu | p.P97L | Q96T75 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.856) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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