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Gene: DDX55 |
Gene summary for DDX55 |
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Gene information | Species | Human | Gene symbol | DDX55 | Gene ID | 57696 |
Gene name | DEAD-box helicase 55 | |
Gene Alias | DDX55 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024RBS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57696 | DDX55 | LZE4T | Human | Esophagus | ESCC | 3.20e-07 | 2.28e-01 | 0.0811 |
57696 | DDX55 | LZE7T | Human | Esophagus | ESCC | 9.26e-09 | 3.63e-01 | 0.0667 |
57696 | DDX55 | LZE24T | Human | Esophagus | ESCC | 8.16e-12 | 2.20e-01 | 0.0596 |
57696 | DDX55 | P1T-E | Human | Esophagus | ESCC | 5.45e-08 | 3.47e-01 | 0.0875 |
57696 | DDX55 | P2T-E | Human | Esophagus | ESCC | 1.31e-34 | 6.07e-01 | 0.1177 |
57696 | DDX55 | P4T-E | Human | Esophagus | ESCC | 4.56e-25 | 4.61e-01 | 0.1323 |
57696 | DDX55 | P5T-E | Human | Esophagus | ESCC | 2.39e-29 | 4.41e-01 | 0.1327 |
57696 | DDX55 | P8T-E | Human | Esophagus | ESCC | 3.20e-25 | 2.15e-01 | 0.0889 |
57696 | DDX55 | P9T-E | Human | Esophagus | ESCC | 6.21e-15 | 1.50e-01 | 0.1131 |
57696 | DDX55 | P10T-E | Human | Esophagus | ESCC | 3.66e-28 | 5.28e-01 | 0.116 |
57696 | DDX55 | P11T-E | Human | Esophagus | ESCC | 1.84e-09 | 4.01e-01 | 0.1426 |
57696 | DDX55 | P12T-E | Human | Esophagus | ESCC | 3.78e-19 | 3.12e-01 | 0.1122 |
57696 | DDX55 | P15T-E | Human | Esophagus | ESCC | 5.76e-16 | 3.58e-01 | 0.1149 |
57696 | DDX55 | P16T-E | Human | Esophagus | ESCC | 2.36e-25 | 5.34e-01 | 0.1153 |
57696 | DDX55 | P17T-E | Human | Esophagus | ESCC | 2.36e-08 | 2.92e-01 | 0.1278 |
57696 | DDX55 | P19T-E | Human | Esophagus | ESCC | 8.93e-03 | 3.53e-01 | 0.1662 |
57696 | DDX55 | P20T-E | Human | Esophagus | ESCC | 1.55e-16 | 3.06e-01 | 0.1124 |
57696 | DDX55 | P21T-E | Human | Esophagus | ESCC | 9.82e-27 | 4.61e-01 | 0.1617 |
57696 | DDX55 | P22T-E | Human | Esophagus | ESCC | 6.44e-09 | 1.50e-01 | 0.1236 |
57696 | DDX55 | P23T-E | Human | Esophagus | ESCC | 2.30e-12 | 3.42e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX55 | SNV | Missense_Mutation | c.633N>G | p.Asn211Lys | p.N211K | Q8NHQ9 | protein_coding | tolerated(0.72) | benign(0) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX55 | SNV | Missense_Mutation | c.1255G>C | p.Glu419Gln | p.E419Q | Q8NHQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.685) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
DDX55 | SNV | Missense_Mutation | c.1244G>C | p.Arg415Thr | p.R415T | Q8NHQ9 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR | |
DDX55 | SNV | Missense_Mutation | c.577N>G | p.Pro193Ala | p.P193A | Q8NHQ9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-D8-A1JE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamicin | SD | |
DDX55 | SNV | Missense_Mutation | c.976G>A | p.Asp326Asn | p.D326N | Q8NHQ9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
DDX55 | deletion | Frame_Shift_Del | c.1591_1592delNN | p.Lys531GlufsTer5 | p.K531Efs*5 | Q8NHQ9 | protein_coding | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |||
DDX55 | insertion | Frame_Shift_Ins | novel | c.1033_1034insATACAGTTTTGGTTTTCAAATGG | p.Pro345HisfsTer58 | p.P345Hfs*58 | Q8NHQ9 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
DDX55 | insertion | Nonsense_Mutation | novel | c.911_912insTTAAAACCCCCAAGGAC | p.Lys304AsnfsTer2 | p.K304Nfs*2 | Q8NHQ9 | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DDX55 | insertion | Nonsense_Mutation | novel | c.1030_1031insGCTTGTAGTTAGGTTGCGTCTGCTGCAGCTATTGCTC | p.Asp344GlyfsTer3 | p.D344Gfs*3 | Q8NHQ9 | protein_coding | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DDX55 | deletion | Frame_Shift_Del | c.1509_1510delNN | p.Lys506AsnfsTer4 | p.K506Nfs*4 | Q8NHQ9 | protein_coding | TCGA-AO-A1KR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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