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Gene: CBX1 |
Gene summary for CBX1 |
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Gene information | Species | Human | Gene symbol | CBX1 | Gene ID | 10951 |
Gene name | chromobox 1 | |
Gene Alias | CBX | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P83916 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10951 | CBX1 | LZE2D | Human | Esophagus | HGIN | 1.13e-03 | 4.80e-01 | 0.0642 |
10951 | CBX1 | LZE2T | Human | Esophagus | ESCC | 5.46e-06 | 1.03e+00 | 0.082 |
10951 | CBX1 | LZE4T | Human | Esophagus | ESCC | 2.54e-26 | 9.35e-01 | 0.0811 |
10951 | CBX1 | LZE5T | Human | Esophagus | ESCC | 2.48e-02 | 3.61e-01 | 0.0514 |
10951 | CBX1 | LZE7T | Human | Esophagus | ESCC | 4.20e-11 | 7.76e-01 | 0.0667 |
10951 | CBX1 | LZE8T | Human | Esophagus | ESCC | 1.86e-03 | 2.12e-01 | 0.067 |
10951 | CBX1 | LZE20T | Human | Esophagus | ESCC | 2.27e-03 | 1.77e-01 | 0.0662 |
10951 | CBX1 | LZE22D1 | Human | Esophagus | HGIN | 1.72e-04 | 1.69e-01 | 0.0595 |
10951 | CBX1 | LZE22T | Human | Esophagus | ESCC | 5.37e-07 | 9.13e-01 | 0.068 |
10951 | CBX1 | LZE24T | Human | Esophagus | ESCC | 9.15e-23 | 7.93e-01 | 0.0596 |
10951 | CBX1 | LZE21T | Human | Esophagus | ESCC | 1.16e-04 | 5.70e-01 | 0.0655 |
10951 | CBX1 | LZE6T | Human | Esophagus | ESCC | 9.17e-05 | 5.34e-01 | 0.0845 |
10951 | CBX1 | P1T-E | Human | Esophagus | ESCC | 1.63e-07 | 4.95e-01 | 0.0875 |
10951 | CBX1 | P2T-E | Human | Esophagus | ESCC | 1.19e-65 | 1.37e+00 | 0.1177 |
10951 | CBX1 | P4T-E | Human | Esophagus | ESCC | 1.21e-58 | 1.53e+00 | 0.1323 |
10951 | CBX1 | P5T-E | Human | Esophagus | ESCC | 8.83e-42 | 9.31e-01 | 0.1327 |
10951 | CBX1 | P8T-E | Human | Esophagus | ESCC | 7.58e-32 | 6.31e-01 | 0.0889 |
10951 | CBX1 | P9T-E | Human | Esophagus | ESCC | 1.50e-25 | 7.62e-01 | 0.1131 |
10951 | CBX1 | P10T-E | Human | Esophagus | ESCC | 1.03e-101 | 1.92e+00 | 0.116 |
10951 | CBX1 | P11T-E | Human | Esophagus | ESCC | 4.00e-19 | 9.04e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBX1 | SNV | Missense_Mutation | novel | c.277N>A | p.Asp93Asn | p.D93N | P83916 | protein_coding | tolerated(0.41) | benign(0.023) | TCGA-B6-A0I1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CBX1 | SNV | Missense_Mutation | c.358N>A | p.Glu120Lys | p.E120K | P83916 | protein_coding | deleterious(0.02) | possibly_damaging(0.668) | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CBX1 | SNV | Missense_Mutation | c.309N>T | p.Lys103Asn | p.K103N | P83916 | protein_coding | deleterious(0.01) | benign(0.227) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
CBX1 | SNV | Missense_Mutation | c.142N>C | p.Glu48Gln | p.E48Q | P83916 | protein_coding | tolerated(0.26) | possibly_damaging(0.54) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
CBX1 | SNV | Missense_Mutation | novel | c.4N>T | p.Gly2Trp | p.G2W | P83916 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CBX1 | SNV | Missense_Mutation | c.184N>A | p.Asp62Asn | p.D62N | P83916 | protein_coding | deleterious(0.01) | benign(0.038) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CBX1 | SNV | Missense_Mutation | c.165A>T | p.Glu55Asp | p.E55D | P83916 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CBX1 | SNV | Missense_Mutation | novel | c.100G>A | p.Gly34Ser | p.G34S | P83916 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6311-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
CBX1 | SNV | Missense_Mutation | c.544G>T | p.Asp182Tyr | p.D182Y | P83916 | protein_coding | deleterious(0) | possibly_damaging(0.543) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CBX1 | SNV | Missense_Mutation | c.79N>A | p.Leu27Ile | p.L27I | P83916 | protein_coding | tolerated(0.21) | probably_damaging(0.987) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10951 | CBX1 | NA | BENSERAZIDE | BENSERAZIDE | ||
10951 | CBX1 | NA | PURPURIN | PURPURIN | ||
10951 | CBX1 | NA | NICARDIPINE | NICARDIPINE | ||
10951 | CBX1 | NA | ROTENONE | ROTENONE | ||
10951 | CBX1 | NA | MITOXANTRONE DIHYDROCHLORIDE | MITOXANTRONE HYDROCHLORIDE | ||
10951 | CBX1 | NA | ATHRAQUINONES A | ATHRAQUINONES A | ||
10951 | CBX1 | NA | METITEPINE | METITEPINE | ||
10951 | CBX1 | NA | CAPSAZEPINE | CAPSAZEPINE | ||
10951 | CBX1 | NA | SURAMIN | SURAMIN | ||
10951 | CBX1 | NA | SB-206553 | CHEMBL297784 |
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