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Gene: CABP4 |
Gene summary for CABP4 |
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Gene information | Species | Human | Gene symbol | CABP4 | Gene ID | 57010 |
Gene name | calcium binding protein 4 | |
Gene Alias | CRSD | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5K4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57010 | CABP4 | HCC2_Meng | Human | Liver | HCC | 4.57e-04 | 6.19e-02 | 0.0107 |
57010 | CABP4 | HCC1 | Human | Liver | HCC | 6.31e-22 | 2.13e+00 | 0.5336 |
57010 | CABP4 | HCC2 | Human | Liver | HCC | 9.31e-46 | 2.35e+00 | 0.5341 |
57010 | CABP4 | HCC5 | Human | Liver | HCC | 1.33e-40 | 2.23e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CABP4 | SNV | Missense_Mutation | rs886048559 | c.194N>G | p.Glu65Gly | p.E65G | P57796 | protein_coding | tolerated(0.08) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CABP4 | SNV | Missense_Mutation | c.655N>C | p.Asp219His | p.D219H | P57796 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
CABP4 | SNV | Missense_Mutation | rs765171666 | c.499G>A | p.Glu167Lys | p.E167K | P57796 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CABP4 | SNV | Missense_Mutation | c.298N>T | p.Arg100Cys | p.R100C | P57796 | protein_coding | deleterious(0.03) | possibly_damaging(0.719) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CABP4 | SNV | Missense_Mutation | c.289N>T | p.His97Tyr | p.H97Y | P57796 | protein_coding | tolerated(0.33) | benign(0.363) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CABP4 | SNV | Missense_Mutation | rs775087763 | c.551G>A | p.Arg184His | p.R184H | P57796 | protein_coding | tolerated(0.33) | benign(0.01) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CABP4 | SNV | Missense_Mutation | c.655N>A | p.Asp219Asn | p.D219N | P57796 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
CABP4 | SNV | Missense_Mutation | c.113N>T | p.Thr38Ile | p.T38I | P57796 | protein_coding | tolerated(0.05) | benign(0.027) | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
CABP4 | SNV | Missense_Mutation | rs374363909 | c.758N>A | p.Arg253Gln | p.R253Q | P57796 | protein_coding | tolerated(0.41) | benign(0.022) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CABP4 | SNV | Missense_Mutation | c.782G>A | p.Gly261Asp | p.G261D | P57796 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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