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Gene: C17orf80 |
Gene summary for C17ORF80 |
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Gene information | Species | Human | Gene symbol | C17orf80 | Gene ID | 55028 |
Gene name | chromosome 17 open reading frame 80 | |
Gene Alias | HLC-8 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BSJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55028 | C17orf80 | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.64e-01 | 0.0811 |
55028 | C17orf80 | LZE24T | Human | Esophagus | ESCC | 1.68e-09 | 2.24e-01 | 0.0596 |
55028 | C17orf80 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 1.76e-01 | 0.0875 |
55028 | C17orf80 | P2T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.23e-01 | 0.1177 |
55028 | C17orf80 | P4T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.28e-01 | 0.1323 |
55028 | C17orf80 | P8T-E | Human | Esophagus | ESCC | 1.05e-18 | 1.84e-01 | 0.0889 |
55028 | C17orf80 | P9T-E | Human | Esophagus | ESCC | 3.05e-03 | 1.07e-01 | 0.1131 |
55028 | C17orf80 | P10T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.58e-01 | 0.116 |
55028 | C17orf80 | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 3.54e-01 | 0.1426 |
55028 | C17orf80 | P12T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.25e-01 | 0.1122 |
55028 | C17orf80 | P15T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.22e-01 | 0.1149 |
55028 | C17orf80 | P16T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.33e-01 | 0.1153 |
55028 | C17orf80 | P20T-E | Human | Esophagus | ESCC | 3.34e-15 | 3.22e-01 | 0.1124 |
55028 | C17orf80 | P21T-E | Human | Esophagus | ESCC | 5.02e-07 | 1.38e-01 | 0.1617 |
55028 | C17orf80 | P22T-E | Human | Esophagus | ESCC | 3.80e-07 | 1.69e-01 | 0.1236 |
55028 | C17orf80 | P24T-E | Human | Esophagus | ESCC | 2.94e-07 | 1.48e-01 | 0.1287 |
55028 | C17orf80 | P26T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.14e-01 | 0.1276 |
55028 | C17orf80 | P27T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.57e-01 | 0.1055 |
55028 | C17orf80 | P28T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.43e-01 | 0.1149 |
55028 | C17orf80 | P30T-E | Human | Esophagus | ESCC | 1.89e-05 | 1.81e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C17orf80 | SNV | Missense_Mutation | novel | c.226N>A | p.Glu76Lys | p.E76K | Q9BSJ5 | protein_coding | tolerated(1) | benign(0.007) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
C17orf80 | SNV | Missense_Mutation | c.211N>C | p.Glu71Gln | p.E71Q | Q9BSJ5 | protein_coding | tolerated(0.19) | possibly_damaging(0.677) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C17orf80 | SNV | Missense_Mutation | c.598N>G | p.Thr200Ala | p.T200A | Q9BSJ5 | protein_coding | tolerated(0.11) | possibly_damaging(0.737) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
C17orf80 | SNV | Missense_Mutation | c.530N>T | p.Ser177Leu | p.S177L | Q9BSJ5 | protein_coding | tolerated(0.22) | possibly_damaging(0.6) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
C17orf80 | SNV | Missense_Mutation | novel | c.949N>G | p.Met317Val | p.M317V | Q9BSJ5 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C17orf80 | SNV | Missense_Mutation | novel | c.1417C>T | p.Leu473Phe | p.L473F | Q9BSJ5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
C17orf80 | SNV | Missense_Mutation | c.1111N>A | p.Ser371Thr | p.S371T | Q9BSJ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.521) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C17orf80 | SNV | Missense_Mutation | rs752447234 | c.1082N>T | p.Thr361Met | p.T361M | Q9BSJ5 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C17orf80 | SNV | Missense_Mutation | c.1372N>G | p.Ser458Gly | p.S458G | Q9BSJ5 | protein_coding | tolerated(0.1) | probably_damaging(0.994) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C17orf80 | SNV | Missense_Mutation | rs778397466 | c.1673C>T | p.Thr558Met | p.T558M | Q9BSJ5 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-G4-6293-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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