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Gene: C16orf62 |
Gene summary for C16ORF62 |
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Gene information | Species | Human | Gene symbol | C16orf62 | Gene ID | 57020 |
Gene name | VPS35 endosomal protein sorting factor like | |
Gene Alias | C16orf62 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KT69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57020 | C16orf62 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.45e-30 | 5.14e-01 | 0.294 |
57020 | C16orf62 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.89e-03 | 4.33e-01 | 0.3487 |
57020 | C16orf62 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.54e-35 | 9.08e-01 | 0.281 |
57020 | C16orf62 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.40e-09 | 2.12e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf62 | SNV | Missense_Mutation | rs751019017 | c.151N>G | p.Cys51Gly | p.C51G | protein_coding | tolerated_low_confidence(0.75) | benign(0) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
C16orf62 | SNV | Missense_Mutation | c.1992N>T | p.Met664Ile | p.M664I | protein_coding | deleterious(0.01) | possibly_damaging(0.487) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||
C16orf62 | SNV | Missense_Mutation | novel | c.629G>T | p.Arg210Leu | p.R210L | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
C16orf62 | SNV | Missense_Mutation | c.2917N>A | p.Leu973Met | p.L973M | protein_coding | tolerated(0.13) | possibly_damaging(0.482) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C16orf62 | SNV | Missense_Mutation | c.2175N>C | p.Leu725Phe | p.L725F | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C16orf62 | SNV | Missense_Mutation | c.326N>A | p.Cys109Tyr | p.C109Y | protein_coding | tolerated(0.91) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
C16orf62 | SNV | Missense_Mutation | rs749175686 | c.1382N>T | p.Thr461Met | p.T461M | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C16orf62 | SNV | Missense_Mutation | novel | c.997N>A | p.Leu333Ile | p.L333I | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
C16orf62 | insertion | Nonsense_Mutation | novel | c.1130_1131insAGATTATGTTTTTCAAAGTTGTTGGTGATCTGA | p.Arg377_Glu378insAspTyrValPheGlnSerCysTrpTerSerGlu | p.R377_E378insDYVFQSCW*SE | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |||
C16orf62 | insertion | Frame_Shift_Ins | novel | c.1798_1799insGGCTTGACCTTCCCCAAACCACTGCCCTA | p.Glu600GlyfsTer22 | p.E600Gfs*22 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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