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Gene: APMAP |
Gene summary for APMAP |
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Gene information | Species | Human | Gene symbol | APMAP | Gene ID | 57136 |
Gene name | adipocyte plasma membrane associated protein | |
Gene Alias | BSCv | |
Cytomap | 20p11.21 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9HDC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57136 | APMAP | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.54e-08 | 2.30e-01 | 0.0155 |
57136 | APMAP | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.99e-04 | 3.43e-01 | -0.1808 |
57136 | APMAP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.94e-13 | 5.93e-01 | -0.0811 |
57136 | APMAP | HTA11_347_2000001011 | Human | Colorectum | AD | 3.04e-06 | 2.70e-01 | -0.1954 |
57136 | APMAP | HTA11_83_2000001011 | Human | Colorectum | SER | 1.04e-03 | 3.52e-01 | -0.1526 |
57136 | APMAP | HTA11_696_2000001011 | Human | Colorectum | AD | 3.48e-02 | 2.08e-01 | -0.1464 |
57136 | APMAP | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.39e-09 | 3.78e-01 | -0.059 |
57136 | APMAP | HTA11_866_3004761011 | Human | Colorectum | AD | 5.50e-13 | 5.12e-01 | 0.096 |
57136 | APMAP | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.09e-04 | 4.74e-01 | 0.0131 |
57136 | APMAP | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.09e-02 | 3.31e-01 | -0.0177 |
57136 | APMAP | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.24e-06 | 8.73e-01 | 0.0171 |
57136 | APMAP | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.88e-18 | 5.17e-01 | 0.0674 |
57136 | APMAP | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.59e-04 | 4.77e-01 | -0.0124 |
57136 | APMAP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.13e-06 | 3.29e-01 | 0.294 |
57136 | APMAP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.27e-08 | 5.66e-01 | 0.281 |
57136 | APMAP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.48e-05 | 3.03e-01 | 0.3859 |
57136 | APMAP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.59e-19 | 5.48e-01 | 0.3005 |
57136 | APMAP | LZE2T | Human | Esophagus | ESCC | 4.13e-06 | 1.26e+00 | 0.082 |
57136 | APMAP | LZE4T | Human | Esophagus | ESCC | 4.09e-26 | 1.01e+00 | 0.0811 |
57136 | APMAP | LZE5T | Human | Esophagus | ESCC | 2.15e-07 | 4.95e-01 | 0.0514 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APMAP | SNV | Missense_Mutation | novel | c.1164N>G | p.Ile388Met | p.I388M | Q9HDC9 | protein_coding | deleterious(0.01) | benign(0.255) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
APMAP | SNV | Missense_Mutation | novel | c.311C>T | p.Ser104Phe | p.S104F | Q9HDC9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
APMAP | SNV | Missense_Mutation | c.392N>G | p.Thr131Ser | p.T131S | Q9HDC9 | protein_coding | tolerated(0.3) | benign(0.034) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | |
APMAP | deletion | Frame_Shift_Del | c.69_78delCCAGGCCCCG | p.Gln24ArgfsTer15 | p.Q24Rfs*15 | Q9HDC9 | protein_coding | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
APMAP | deletion | Frame_Shift_Del | rs777444320 | c.945delN | p.Tyr316ThrfsTer29 | p.Y316Tfs*29 | Q9HDC9 | protein_coding | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | ||
APMAP | SNV | Missense_Mutation | rs149631598 | c.856N>A | p.Val286Ile | p.V286I | Q9HDC9 | protein_coding | tolerated(0.13) | benign(0.047) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
APMAP | SNV | Missense_Mutation | c.274N>A | p.Glu92Lys | p.E92K | Q9HDC9 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
APMAP | SNV | Missense_Mutation | c.1105G>A | p.Asp369Asn | p.D369N | Q9HDC9 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-AA-3511-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
APMAP | SNV | Missense_Mutation | c.461G>A | p.Gly154Asp | p.G154D | Q9HDC9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
APMAP | SNV | Missense_Mutation | rs774016612 | c.925C>T | p.Arg309Trp | p.R309W | Q9HDC9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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