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Gene: ACYP2 |
Gene summary for ACYP2 |
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Gene information | Species | Human | Gene symbol | ACYP2 | Gene ID | 98 |
Gene name | acylphosphatase 2 | |
Gene Alias | ACYM | |
Cytomap | 2p16.2 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | U3KQL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
98 | ACYP2 | CCI_1 | Human | Cervix | CC | 1.43e-02 | 5.83e-01 | 0.528 |
98 | ACYP2 | CCI_2 | Human | Cervix | CC | 8.87e-03 | 6.02e-01 | 0.5249 |
98 | ACYP2 | CCI_3 | Human | Cervix | CC | 1.06e-06 | 6.71e-01 | 0.516 |
98 | ACYP2 | AEH-subject1 | Human | Endometrium | AEH | 1.94e-10 | 3.87e-01 | -0.3059 |
98 | ACYP2 | AEH-subject3 | Human | Endometrium | AEH | 5.39e-03 | 2.34e-01 | -0.2576 |
98 | ACYP2 | AEH-subject4 | Human | Endometrium | AEH | 2.75e-05 | 3.30e-01 | -0.2657 |
98 | ACYP2 | AEH-subject5 | Human | Endometrium | AEH | 1.15e-02 | 2.73e-01 | -0.2953 |
98 | ACYP2 | EEC-subject2 | Human | Endometrium | EEC | 7.29e-06 | 3.02e-01 | -0.2607 |
98 | ACYP2 | EEC-subject3 | Human | Endometrium | EEC | 1.25e-03 | 2.02e-02 | -0.2525 |
98 | ACYP2 | EEC-subject4 | Human | Endometrium | EEC | 2.91e-04 | 3.34e-01 | -0.2571 |
98 | ACYP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.65e-04 | -9.18e-02 | -0.1869 |
98 | ACYP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.25e-04 | -3.64e-02 | -0.1875 |
98 | ACYP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.38e-05 | -9.73e-02 | -0.1883 |
98 | ACYP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.52e-05 | -1.07e-01 | -0.1934 |
98 | ACYP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.48e-08 | -1.02e-01 | -0.1917 |
98 | ACYP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.30e-11 | -1.01e-01 | -0.1916 |
98 | ACYP2 | LZE2T | Human | Esophagus | ESCC | 4.58e-04 | 4.61e-01 | 0.082 |
98 | ACYP2 | LZE4T | Human | Esophagus | ESCC | 3.44e-08 | 2.42e-01 | 0.0811 |
98 | ACYP2 | LZE5T | Human | Esophagus | ESCC | 1.06e-03 | 2.42e-01 | 0.0514 |
98 | ACYP2 | LZE7T | Human | Esophagus | ESCC | 7.71e-06 | 3.30e-01 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0062010 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
hsa0062013 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
hsa0062023 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0062033 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa006208 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa0062011 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa0062021 | Liver | HCC | Pyruvate metabolism | 37/4020 | 47/8465 | 1.10e-05 | 8.03e-05 | 4.46e-05 | 37 |
hsa0062031 | Liver | HCC | Pyruvate metabolism | 37/4020 | 47/8465 | 1.10e-05 | 8.03e-05 | 4.46e-05 | 37 |
hsa006209 | Oral cavity | OSCC | Pyruvate metabolism | 31/3704 | 47/8465 | 1.74e-03 | 4.73e-03 | 2.41e-03 | 31 |
hsa0062012 | Oral cavity | OSCC | Pyruvate metabolism | 31/3704 | 47/8465 | 1.74e-03 | 4.73e-03 | 2.41e-03 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACYP2 | SNV | Missense_Mutation | novel | c.421N>G | p.Lys141Glu | p.K141E | protein_coding | tolerated_low_confidence(0.2) | benign(0.108) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACYP2 | SNV | Missense_Mutation | c.314N>C | p.Arg105Thr | p.R105T | protein_coding | tolerated(0.47) | benign(0.103) | TCGA-38-4626-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ACYP2 | SNV | Missense_Mutation | c.304G>T | p.Asp102Tyr | p.D102Y | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | ||
ACYP2 | SNV | Missense_Mutation | c.289N>G | p.Arg97Gly | p.R97G | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ACYP2 | SNV | Missense_Mutation | c.436N>G | p.Ser146Gly | p.S146G | protein_coding | tolerated(0.2) | benign(0.091) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
98 | ACYP2 | NA | cisplatin | CISPLATIN | 26928270,31666714 |
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