GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:004311218 | Esophagus | ESCC | receptor metabolic process | 104/8552 | 166/18723 | 7.44e-06 | 7.37e-05 | 104 |
GO:00066561 | Esophagus | ESCC | phosphatidylcholine biosynthetic process | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00019192 | Esophagus | ESCC | regulation of receptor recycling | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00018813 | Esophagus | ESCC | receptor recycling | 25/8552 | 33/18723 | 4.30e-04 | 2.43e-03 | 25 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:01201624 | Esophagus | ESCC | positive regulation of cold-induced thermogenesis | 57/8552 | 97/18723 | 6.43e-03 | 2.35e-02 | 57 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACHE | SNV | Missense_Mutation | novel | c.889G>T | p.Asp297Tyr | p.D297Y | P22303 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ACHE | SNV | Missense_Mutation | | c.1243N>A | p.Asp415Asn | p.D415N | P22303 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ACHE | SNV | Missense_Mutation | | c.323A>G | p.Tyr108Cys | p.Y108C | P22303 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ACHE | SNV | Missense_Mutation | novel | c.1427N>G | p.Val476Gly | p.V476G | P22303 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ACHE | insertion | In_Frame_Ins | novel | c.146_147insTAAAATGGGATCGCTAGTGGAAATGAGGTGGGA | p.Arg49_Gly50insLysMetGlySerLeuValGluMetArgTrpGlu | p.R49_G50insKMGSLVEMRWE | P22303 | protein_coding | | | TCGA-AO-A0JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ACHE | SNV | Missense_Mutation | novel | c.64C>A | p.Leu22Ile | p.L22I | P22303 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACHE | SNV | Missense_Mutation | novel | c.1495G>C | p.Glu499Gln | p.E499Q | P22303 | protein_coding | tolerated(0.16) | benign(0.017) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ACHE | SNV | Missense_Mutation | | c.1348G>A | p.Ala450Thr | p.A450T | P22303 | protein_coding | tolerated(0.07) | benign(0.209) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ACHE | SNV | Missense_Mutation | novel | c.373N>C | p.Glu125Gln | p.E125Q | P22303 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ACHE | SNV | Missense_Mutation | rs780793869 | c.247C>T | p.Pro83Ser | p.P83S | P22303 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | 4-PAM derivative 1 | | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | Edrophonium | EDROPHONIUM | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | Rivastigmine | RIVASTIGMINE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | RIVASTIGMINE | RIVASTIGMINE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | PMID29757691-Compound-7 | | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | inhibitor | CHEMBL1025 | ISOFLUROPHATE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | ACOTIAMIDE | ACOTIAMIDE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | inhibitor | 310264771 | NEOSTIGMINE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | PHYSOSTIGMINE | PHYSOSTIGMINE | |
43 | ACHE | ENZYME, CELL SURFACE, DRUGGABLE GENOME | | TURBINATINE | TURBINATINE | 15568781 |