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Gene: ZNF511 |
Gene summary for ZNF511 |
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Gene information | Species | Human | Gene symbol | ZNF511 | Gene ID | 118472 |
Gene name | zinc finger protein 511 | |
Gene Alias | Zfp511 | |
Cytomap | 10q26.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NB15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118472 | ZNF511 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.00e-08 | 1.79e-01 | 0.0155 |
118472 | ZNF511 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 2.83e-01 | -0.1808 |
118472 | ZNF511 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 2.22e-01 | 0.0216 |
118472 | ZNF511 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-09 | 3.40e-01 | -0.0811 |
118472 | ZNF511 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.68e-05 | 1.76e-01 | -0.1088 |
118472 | ZNF511 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.75e-13 | 2.61e-01 | -0.1954 |
118472 | ZNF511 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 3.68e-01 | -0.2602 |
118472 | ZNF511 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 3.67e-01 | -0.2196 |
118472 | ZNF511 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.09e-06 | 2.24e-01 | -0.1207 |
118472 | ZNF511 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.73e-04 | 1.63e-01 | -0.1526 |
118472 | ZNF511 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.92e-23 | 4.31e-01 | -0.1464 |
118472 | ZNF511 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.55e-09 | 1.93e-01 | -0.1001 |
118472 | ZNF511 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.70e-18 | 4.63e-01 | -0.059 |
118472 | ZNF511 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.59e-01 | -0.2061 |
118472 | ZNF511 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.36e-01 | -0.1462 |
118472 | ZNF511 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.42e-10 | 3.74e-01 | -0.0842 |
118472 | ZNF511 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.34e-01 | -0.0179 |
118472 | ZNF511 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.30e-21 | 4.25e-01 | 0.096 |
118472 | ZNF511 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.90e-01 | 0.0446 |
118472 | ZNF511 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.04e-18 | 6.87e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF511 | insertion | Frame_Shift_Ins | novel | c.605_606insCAGACTTATTAAGCACTTGTGT | p.Glu202AspfsTer15 | p.E202Dfs*15 | Q8NB15 | protein_coding | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
ZNF511 | SNV | Missense_Mutation | c.694N>G | p.Ile232Val | p.I232V | Q8NB15 | protein_coding | tolerated(0.48) | benign(0.01) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF511 | SNV | Missense_Mutation | rs776627133 | c.517G>A | p.Ala173Thr | p.A173T | Q8NB15 | protein_coding | tolerated(0.32) | benign(0.055) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZNF511 | SNV | Missense_Mutation | rs747203864 | c.592N>T | p.Arg198Trp | p.R198W | Q8NB15 | protein_coding | deleterious(0.04) | possibly_damaging(0.627) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ZNF511 | SNV | Missense_Mutation | rs200701211 | c.527N>A | p.Arg176Gln | p.R176Q | Q8NB15 | protein_coding | deleterious(0.01) | possibly_damaging(0.854) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF511 | SNV | Missense_Mutation | c.635N>T | p.Ala212Val | p.A212V | Q8NB15 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-BG-A18B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF511 | SNV | Missense_Mutation | rs771125116 | c.664N>T | p.Arg222Trp | p.R222W | Q8NB15 | protein_coding | deleterious(0.05) | probably_damaging(0.967) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF511 | SNV | Missense_Mutation | novel | c.341G>C | p.Arg114Pro | p.R114P | Q8NB15 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF511 | SNV | Missense_Mutation | c.703G>T | p.Gly235Cys | p.G235C | Q8NB15 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF511 | SNV | Missense_Mutation | rs746249082 | c.236N>T | p.Ala79Val | p.A79V | Q8NB15 | protein_coding | deleterious(0.02) | benign(0.121) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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