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Gene: ZNF507 |
Gene summary for ZNF507 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF507 | Gene ID | 22847 |
| Gene name | zinc finger protein 507 | |
| Gene Alias | Zfp507 | |
| Cytomap | 19q13.11 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TCN5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22847 | ZNF507 | male-WTA | Human | Thyroid | PTC | 6.62e-13 | 1.19e-01 | 0.1037 |
| 22847 | ZNF507 | PTC01 | Human | Thyroid | PTC | 4.35e-03 | 3.83e-02 | 0.1899 |
| 22847 | ZNF507 | PTC03 | Human | Thyroid | PTC | 1.98e-03 | 1.32e-01 | 0.1784 |
| 22847 | ZNF507 | PTC04 | Human | Thyroid | PTC | 1.86e-13 | 1.96e-01 | 0.1927 |
| 22847 | ZNF507 | PTC05 | Human | Thyroid | PTC | 1.83e-14 | 3.85e-01 | 0.2065 |
| 22847 | ZNF507 | PTC06 | Human | Thyroid | PTC | 7.34e-16 | 3.07e-01 | 0.2057 |
| 22847 | ZNF507 | PTC07 | Human | Thyroid | PTC | 4.34e-14 | 3.10e-01 | 0.2044 |
| 22847 | ZNF507 | ATC12 | Human | Thyroid | ATC | 5.28e-04 | 9.96e-02 | 0.34 |
| 22847 | ZNF507 | ATC13 | Human | Thyroid | ATC | 3.83e-29 | 5.51e-01 | 0.34 |
| 22847 | ZNF507 | ATC2 | Human | Thyroid | ATC | 1.66e-07 | 4.83e-01 | 0.34 |
| 22847 | ZNF507 | ATC4 | Human | Thyroid | ATC | 2.57e-07 | 1.30e-01 | 0.34 |
| 22847 | ZNF507 | ATC5 | Human | Thyroid | ATC | 9.47e-37 | 6.07e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | CRC |  |
| Stomach | GC |  |
| Stomach | CAG with IM |  |
| Stomach | CSG |  |
| Stomach | CAG |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF507 | CT | Colorectum | CRC | AP000787.1,MKKS,UNC50, etc. | 1.09e-02 |  |
| ZNF507 | TFH | Colorectum | AD | COX20,ARID5A,UBXN2A, etc. | 0.00e+00 |  |
| ZNF507 | BN | Colorectum | AD | COX20,ARID5A,UBXN2A, etc. | 0.00e+00 | |
| ZNF507 | ILC | Colorectum | ADJ | COX20,ARID5A,UBXN2A, etc. | 1.43e-02 |  |
| ZNF507 | TFH | Colorectum | CRC | COX20,ARID5A,UBXN2A, etc. | 0.00e+00 | |
| ZNF507 | BN | Colorectum | CRC | COX20,ARID5A,UBXN2A, etc. | 7.54e-02 | |
| ZNF507 | TH1 | Colorectum | CRC | COX20,ARID5A,UBXN2A, etc. | -2.22e-16 | |
| ZNF507 | TH17 | Colorectum | FAP | COX20,ARID5A,UBXN2A, etc. | 4.69e-02 |  |
| ZNF507 | CD8TEXINT | Colorectum | FAP | COX20,ARID5A,UBXN2A, etc. | 1.52e-02 | |
| ZNF507 | ILC | Colorectum | FAP | COX20,ARID5A,UBXN2A, etc. | 1.52e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF507 | SNV | Missense_Mutation | novel | c.2524N>A | p.Gln842Lys | p.Q842K | Q8TCN5 | protein_coding | tolerated(0.91) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF507 | SNV | Missense_Mutation | novel | c.1654N>A | p.Asp552Asn | p.D552N | Q8TCN5 | protein_coding | tolerated(0.16) | benign(0) | TCGA-PE-A5DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | |
| ZNF507 | insertion | Nonsense_Mutation | novel | c.1025_1026insTTTTATTTAATTTCATTTATATAGTACTTTCCCAAATTCAAT | p.Ala342_Glu343insPheIleTerPheHisLeuTyrSerThrPheProAsnSerIle | p.A342_E343insFI*FHLYSTFPNSI | Q8TCN5 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| ZNF507 | insertion | Frame_Shift_Ins | novel | c.74_75insAACAGCCATGATTCACCACC | p.Ser25ArgfsTer27 | p.S25Rfs*27 | Q8TCN5 | protein_coding | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ZNF507 | insertion | Frame_Shift_Ins | novel | c.792_793insGTACTTTCCCAAATTCAATATGCCCTGTACAAACTACATG | p.Thr265ValfsTer24 | p.T265Vfs*24 | Q8TCN5 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
| ZNF507 | insertion | Nonsense_Mutation | novel | c.364_365insAAAATACTTAGATGAGATTACAGACA | p.Ala122GlufsTer4 | p.A122Efs*4 | Q8TCN5 | protein_coding | TCGA-AN-A0AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
| ZNF507 | SNV | Missense_Mutation | c.2858N>T | p.Asn953Ile | p.N953I | Q8TCN5 | protein_coding | deleterious_low_confidence(0) | benign(0.143) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF507 | SNV | Missense_Mutation | c.2423N>G | p.His808Arg | p.H808R | Q8TCN5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF507 | SNV | Missense_Mutation | c.1751N>A | p.Ser584Asn | p.S584N | Q8TCN5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| ZNF507 | SNV | Missense_Mutation | rs371931412 | c.1931N>A | p.Arg644His | p.R644H | Q8TCN5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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