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Gene: ZNF154 |
Gene summary for ZNF154 |
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Gene information | Species | Human | Gene symbol | ZNF154 | Gene ID | 7710 |
Gene name | zinc finger protein 154 | |
Gene Alias | pHZ-92 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4Q0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7710 | ZNF154 | HCC1 | Human | Liver | HCC | 1.12e-14 | 1.65e+00 | 0.5336 |
7710 | ZNF154 | HCC2 | Human | Liver | HCC | 2.37e-18 | 1.63e+00 | 0.5341 |
7710 | ZNF154 | HCC5 | Human | Liver | HCC | 5.17e-15 | 1.12e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF154 | SNV | Missense_Mutation | novel | c.1130N>T | p.Arg377Ile | p.R377I | Q13106 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF154 | SNV | Missense_Mutation | novel | c.49N>C | p.Glu17Gln | p.E17Q | Q13106 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF154 | deletion | Frame_Shift_Del | novel | c.560delN | p.Lys187SerfsTer103 | p.K187Sfs*103 | Q13106 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF154 | deletion | Frame_Shift_Del | novel | c.259delN | p.Glu87SerfsTer203 | p.E87Sfs*203 | Q13106 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF154 | SNV | Missense_Mutation | novel | c.377N>T | p.Ser126Ile | p.S126I | Q13106 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF154 | SNV | Missense_Mutation | c.135N>C | p.Glu45Asp | p.E45D | Q13106 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF154 | SNV | Missense_Mutation | novel | c.259G>A | p.Glu87Lys | p.E87K | Q13106 | protein_coding | tolerated(1) | benign(0) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF154 | SNV | Missense_Mutation | c.59C>T | p.Ala20Val | p.A20V | Q13106 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF154 | SNV | Missense_Mutation | rs748637241 | c.1195G>A | p.Gly399Ser | p.G399S | Q13106 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF154 | SNV | Missense_Mutation | rs773669101 | c.623G>A | p.Arg208Gln | p.R208Q | Q13106 | protein_coding | tolerated(1) | benign(0.019) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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