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Gene: ZBTB25 |
Gene summary for ZBTB25 |
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Gene information | Species | Human | Gene symbol | ZBTB25 | Gene ID | 7597 |
Gene name | zinc finger and BTB domain containing 25 | |
Gene Alias | C14orf51 | |
Cytomap | 14q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P24278 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7597 | ZBTB25 | LZE4T | Human | Esophagus | ESCC | 3.90e-09 | 2.41e-01 | 0.0811 |
7597 | ZBTB25 | LZE24T | Human | Esophagus | ESCC | 2.62e-08 | 2.74e-01 | 0.0596 |
7597 | ZBTB25 | LZE21T | Human | Esophagus | ESCC | 2.58e-03 | 2.24e-01 | 0.0655 |
7597 | ZBTB25 | P2T-E | Human | Esophagus | ESCC | 2.58e-11 | 2.41e-01 | 0.1177 |
7597 | ZBTB25 | P4T-E | Human | Esophagus | ESCC | 8.49e-12 | 1.86e-01 | 0.1323 |
7597 | ZBTB25 | P5T-E | Human | Esophagus | ESCC | 3.50e-05 | 1.51e-01 | 0.1327 |
7597 | ZBTB25 | P8T-E | Human | Esophagus | ESCC | 3.78e-09 | 1.49e-01 | 0.0889 |
7597 | ZBTB25 | P9T-E | Human | Esophagus | ESCC | 1.09e-04 | 9.18e-02 | 0.1131 |
7597 | ZBTB25 | P10T-E | Human | Esophagus | ESCC | 5.71e-26 | 4.99e-01 | 0.116 |
7597 | ZBTB25 | P11T-E | Human | Esophagus | ESCC | 1.01e-04 | 3.06e-01 | 0.1426 |
7597 | ZBTB25 | P12T-E | Human | Esophagus | ESCC | 5.71e-19 | 3.79e-01 | 0.1122 |
7597 | ZBTB25 | P15T-E | Human | Esophagus | ESCC | 3.10e-28 | 6.68e-01 | 0.1149 |
7597 | ZBTB25 | P16T-E | Human | Esophagus | ESCC | 2.71e-14 | 2.32e-01 | 0.1153 |
7597 | ZBTB25 | P17T-E | Human | Esophagus | ESCC | 2.76e-02 | 2.39e-01 | 0.1278 |
7597 | ZBTB25 | P20T-E | Human | Esophagus | ESCC | 2.37e-07 | 1.66e-01 | 0.1124 |
7597 | ZBTB25 | P21T-E | Human | Esophagus | ESCC | 2.13e-14 | 2.35e-01 | 0.1617 |
7597 | ZBTB25 | P22T-E | Human | Esophagus | ESCC | 5.67e-13 | 2.65e-01 | 0.1236 |
7597 | ZBTB25 | P23T-E | Human | Esophagus | ESCC | 5.36e-04 | 1.41e-01 | 0.108 |
7597 | ZBTB25 | P24T-E | Human | Esophagus | ESCC | 1.41e-04 | 7.58e-02 | 0.1287 |
7597 | ZBTB25 | P26T-E | Human | Esophagus | ESCC | 7.41e-27 | 4.12e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB25 | SNV | Missense_Mutation | c.662C>T | p.Pro221Leu | p.P221L | P24278 | protein_coding | deleterious(0.01) | benign(0.033) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZBTB25 | deletion | Frame_Shift_Del | novel | c.426delN | p.Lys142AsnfsTer72 | p.K142Nfs*72 | P24278 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZBTB25 | SNV | Missense_Mutation | c.386A>G | p.Tyr129Cys | p.Y129C | P24278 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
ZBTB25 | SNV | Missense_Mutation | rs772027302 | c.1139N>A | p.Arg380Gln | p.R380Q | P24278 | protein_coding | deleterious(0.03) | benign(0.011) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB25 | SNV | Missense_Mutation | rs760872937 | c.281G>A | p.Arg94His | p.R94H | P24278 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZBTB25 | insertion | Frame_Shift_Ins | novel | c.733dupG | p.Glu245GlyfsTer4 | p.E245Gfs*4 | P24278 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
ZBTB25 | SNV | Missense_Mutation | c.573G>T | p.Gln191His | p.Q191H | P24278 | protein_coding | tolerated(0.16) | possibly_damaging(0.628) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB25 | SNV | Missense_Mutation | c.1282A>C | p.Asn428His | p.N428H | P24278 | protein_coding | deleterious(0.01) | benign(0.172) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB25 | SNV | Missense_Mutation | c.827N>A | p.Ser276Asn | p.S276N | P24278 | protein_coding | tolerated(0.2) | benign(0.158) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ZBTB25 | SNV | Missense_Mutation | novel | c.10N>T | p.Ala4Ser | p.A4S | P24278 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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