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Gene: XACT |
Gene summary for XACT |
Gene summary. |
Gene information | Species | Human | Gene symbol | XACT | Gene ID | 105463123 |
Gene name | X active specific transcript | |
Gene Alias | XACT | |
Cytomap | Xq23 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
105463123 | XACT | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.83e-11 | -8.60e-01 | -0.1808 |
105463123 | XACT | HTA11_347_2000001011 | Human | Colorectum | AD | 2.97e-03 | 3.16e-01 | -0.1954 |
105463123 | XACT | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.47e-02 | -5.40e-01 | -0.1207 |
105463123 | XACT | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.45e-05 | 8.86e-01 | -0.059 |
105463123 | XACT | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.40e-04 | -8.99e-01 | -0.1706 |
105463123 | XACT | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.44e-07 | -1.04e+00 | -0.1462 |
105463123 | XACT | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.57e-03 | -6.69e-01 | -0.0179 |
105463123 | XACT | HTA11_866_3004761011 | Human | Colorectum | AD | 1.87e-05 | -5.49e-01 | 0.096 |
105463123 | XACT | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.33e-14 | -1.29e+00 | 0.0528 |
105463123 | XACT | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.93e-08 | -1.29e+00 | 0.0171 |
105463123 | XACT | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.61e-14 | -6.74e-01 | 0.0674 |
105463123 | XACT | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.35e-03 | -9.92e-01 | -0.0124 |
105463123 | XACT | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.24e-20 | -7.74e-01 | 0.294 |
105463123 | XACT | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.93e-03 | -1.36e+00 | 0.3487 |
105463123 | XACT | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.46e-07 | 1.12e+00 | 0.281 |
105463123 | XACT | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.96e-66 | -1.43e+00 | 0.3859 |
105463123 | XACT | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.38e-19 | -1.25e+00 | 0.2585 |
105463123 | XACT | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.51e-81 | -1.53e+00 | 0.3005 |
105463123 | XACT | A002-C-010 | Human | Colorectum | FAP | 7.84e-67 | 7.22e-01 | 0.242 |
105463123 | XACT | A002-C-201 | Human | Colorectum | FAP | 9.28e-31 | 5.51e-01 | 0.0324 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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