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Gene: UMAD1 |
Gene summary for UMAD1 |
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Gene information | Species | Human | Gene symbol | UMAD1 | Gene ID | 729852 |
Gene name | UBAP1-MVB12-associated (UMA) domain containing 1 | |
Gene Alias | RPA3-AS1 | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A4D104 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
729852 | UMAD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-27 | -7.81e-01 | 0.0155 |
729852 | UMAD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.69e-14 | -7.54e-01 | -0.1808 |
729852 | UMAD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.24e-05 | -8.04e-01 | 0.0216 |
729852 | UMAD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-13 | -7.90e-01 | -0.0811 |
729852 | UMAD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.44e-15 | -7.37e-01 | -0.1088 |
729852 | UMAD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.66e-23 | -7.29e-01 | -0.1954 |
729852 | UMAD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.06e-03 | -8.04e-01 | -0.2602 |
729852 | UMAD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.44e-04 | -8.04e-01 | -0.2196 |
729852 | UMAD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.29e-12 | -7.78e-01 | -0.1207 |
729852 | UMAD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.26e-13 | -8.04e-01 | -0.1526 |
729852 | UMAD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.55e-35 | -7.64e-01 | -0.1464 |
729852 | UMAD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.60e-37 | -7.81e-01 | -0.1001 |
729852 | UMAD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.11e-21 | -7.68e-01 | -0.059 |
729852 | UMAD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.17e-04 | -7.75e-01 | -0.1706 |
729852 | UMAD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.33e-05 | -7.78e-01 | -0.2061 |
729852 | UMAD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.15e-02 | -7.36e-01 | -0.1462 |
729852 | UMAD1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.98e-09 | -7.86e-01 | -0.0842 |
729852 | UMAD1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.06e-03 | -8.04e-01 | -0.00410000000000005 |
729852 | UMAD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.67e-09 | -8.04e-01 | -0.0179 |
729852 | UMAD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.03e-24 | -7.84e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UMAD1 | SNV | Missense_Mutation | novel | c.182T>C | p.Val61Ala | p.V61A | protein_coding | tolerated(0.16) | benign(0.085) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
UMAD1 | SNV | Missense_Mutation | novel | c.171T>G | p.Asn57Lys | p.N57K | protein_coding | tolerated(0.73) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
UMAD1 | SNV | Missense_Mutation | rs749662057 | c.179N>A | p.Ser60Asn | p.S60N | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UMAD1 | SNV | Missense_Mutation | rs757161472 | c.352G>A | p.Glu118Lys | p.E118K | protein_coding | tolerated(0.1) | benign(0.325) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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