Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00301008 | Cervix | CC | regulation of endocytosis | 47/2311 | 211/18723 | 3.65e-05 | 5.82e-04 | 47 |
GO:00458077 | Cervix | CC | positive regulation of endocytosis | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:00725836 | Cervix | CC | clathrin-dependent endocytosis | 16/2311 | 47/18723 | 9.56e-05 | 1.25e-03 | 16 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00609984 | Cervix | CC | regulation of dendritic spine development | 18/2311 | 61/18723 | 2.84e-04 | 3.07e-03 | 18 |
GO:00995322 | Cervix | CC | synaptic vesicle endosomal processing | 6/2311 | 10/18723 | 4.73e-04 | 4.68e-03 | 6 |
GO:00303077 | Cervix | CC | positive regulation of cell growth | 36/2311 | 166/18723 | 4.84e-04 | 4.75e-03 | 36 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:19052442 | Cervix | CC | regulation of modification of synaptic structure | 6/2311 | 13/18723 | 2.78e-03 | 1.87e-02 | 6 |
GO:00484883 | Cervix | CC | synaptic vesicle endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
GO:01402383 | Cervix | CC | presynaptic endocytosis | 16/2311 | 62/18723 | 2.87e-03 | 1.91e-02 | 16 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TSN | CD8TCM | Colorectum | AD | CHI3L2,SPARCL1,TIPRL, etc. | 7.32e-02 | |
TSN | MAST | Colorectum | ADJ | CHI3L2,SPARCL1,TIPRL, etc. | 9.13e-02 | |
TSN | CD8TCM | Colorectum | ADJ | CHI3L2,SPARCL1,TIPRL, etc. | 3.24e-02 | |
TSN | CD8TCM | Colorectum | FAP | CHI3L2,SPARCL1,TIPRL, etc. | 5.36e-02 | |
TSN | GC | Colorectum | MSI-H | CHI3L2,SPARCL1,TIPRL, etc. | 7.18e-02 | |
TSN | GC | Colorectum | SER | CHI3L2,SPARCL1,TIPRL, etc. | 3.22e-02 | |
TSN | DIFF | Esophagus | Healthy | MSMO1,NMU,RHEB, etc. | 1.12e-01 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSN | insertion | In_Frame_Ins | novel | c.453_453+1insTCTTTATTA | p.Ser152_Arg153insLeuLeuSer | p.S152_R153insLLS | Q15631 | protein_coding | | | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TSN | SNV | Missense_Mutation | | c.464C>A | p.Ser155Tyr | p.S155Y | Q15631 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TSN | SNV | Missense_Mutation | | c.475N>A | p.Val159Met | p.V159M | Q15631 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR |
TSN | SNV | Missense_Mutation | | c.268N>T | p.His90Tyr | p.H90Y | Q15631 | protein_coding | deleterious(0.01) | possibly_damaging(0.895) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSN | SNV | Missense_Mutation | novel | c.586N>A | p.Asp196Asn | p.D196N | Q15631 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TSN | SNV | Missense_Mutation | novel | c.634N>A | p.Leu212Ile | p.L212I | Q15631 | protein_coding | tolerated(0.22) | possibly_damaging(0.748) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
TSN | SNV | Missense_Mutation | novel | c.362N>G | p.Glu121Gly | p.E121G | Q15631 | protein_coding | deleterious(0.03) | possibly_damaging(0.664) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TSN | SNV | Missense_Mutation | | c.622N>T | p.Val208Leu | p.V208L | Q15631 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TSN | SNV | Missense_Mutation | rs774578869 | c.524A>G | p.Asn175Ser | p.N175S | Q15631 | protein_coding | tolerated(0.67) | benign(0.027) | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
TSN | SNV | Missense_Mutation | | c.34N>A | p.Gly12Ser | p.G12S | Q15631 | protein_coding | tolerated(0.75) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |