GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190165324 | Thyroid | HT | cellular response to peptide | 46/1272 | 359/18723 | 2.46e-05 | 5.48e-04 | 46 |
GO:004343427 | Thyroid | HT | response to peptide hormone | 49/1272 | 414/18723 | 1.05e-04 | 1.75e-03 | 49 |
GO:19908455 | Thyroid | HT | adaptive thermogenesis | 22/1272 | 157/18723 | 9.54e-04 | 9.83e-03 | 22 |
GO:00016595 | Thyroid | HT | temperature homeostasis | 23/1272 | 174/18723 | 1.64e-03 | 1.50e-02 | 23 |
GO:01061067 | Thyroid | HT | cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:01201617 | Thyroid | HT | regulation of cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:007137519 | Thyroid | HT | cellular response to peptide hormone stimulus | 33/1272 | 290/18723 | 2.53e-03 | 2.12e-02 | 33 |
GO:1901653111 | Thyroid | PTC | cellular response to peptide | 169/5968 | 359/18723 | 9.81e-10 | 2.89e-08 | 169 |
GO:0043434113 | Thyroid | PTC | response to peptide hormone | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0071375110 | Thyroid | PTC | cellular response to peptide hormone stimulus | 136/5968 | 290/18723 | 5.49e-08 | 1.17e-06 | 136 |
GO:000975519 | Thyroid | PTC | hormone-mediated signaling pathway | 80/5968 | 190/18723 | 1.84e-03 | 9.91e-03 | 80 |
GO:010610613 | Thyroid | PTC | cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:012016113 | Thyroid | PTC | regulation of cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:199084513 | Thyroid | PTC | adaptive thermogenesis | 64/5968 | 157/18723 | 1.14e-02 | 4.50e-02 | 64 |
GO:190165325 | Thyroid | ATC | cellular response to peptide | 173/6293 | 359/18723 | 5.87e-09 | 1.28e-07 | 173 |
GO:004343428 | Thyroid | ATC | response to peptide hormone | 192/6293 | 414/18723 | 3.63e-08 | 6.70e-07 | 192 |
GO:007137524 | Thyroid | ATC | cellular response to peptide hormone stimulus | 138/6293 | 290/18723 | 4.90e-07 | 7.05e-06 | 138 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:199084521 | Thyroid | ATC | adaptive thermogenesis | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSHR | SNV | Missense_Mutation | rs747590314 | c.739N>A | p.Glu247Lys | p.E247K | | protein_coding | tolerated(0.07) | benign(0.351) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TSHR | SNV | Missense_Mutation | | c.1960A>G | p.Ile654Val | p.I654V | | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSHR | SNV | Missense_Mutation | novel | c.1143T>A | p.Phe381Leu | p.F381L | | protein_coding | deleterious(0.04) | possibly_damaging(0.861) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
TSHR | SNV | Missense_Mutation | | c.782N>T | p.Lys261Met | p.K261M | | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSHR | SNV | Missense_Mutation | | c.1370N>A | p.Ala457Asp | p.A457D | | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSHR | SNV | Missense_Mutation | novel | c.933G>C | p.Gln311His | p.Q311H | | protein_coding | tolerated(0.22) | benign(0.009) | TCGA-OL-A5RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSHR | insertion | Frame_Shift_Ins | novel | c.152_153insTTTCGGAGGATGGAGAAATA | p.Pro52PhefsTer13 | p.P52Ffs*13 | | protein_coding | | | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
TSHR | deletion | Frame_Shift_Del | novel | c.595delN | p.Thr200GlnfsTer8 | p.T200Qfs*8 | | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
TSHR | SNV | Missense_Mutation | novel | c.2206N>A | p.Glu736Lys | p.E736K | | protein_coding | tolerated(0.08) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TSHR | SNV | Missense_Mutation | rs368452281 | c.2120N>A | p.Arg707Gln | p.R707Q | | protein_coding | deleterious(0.03) | benign(0.091) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | SIBUTRAMINE HYDROCHLORIDE | SIBUTRAMINE HYDROCHLORIDE | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | (S)-FLUOXETINE | CHEMBL1169388 | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | BERGAMOTTIN | BERGAMOTTIN | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | THYROTROPIN ALFA | | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | DECANOIC ACID | DECANOIC ACID | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | (S)-VERAPAMIL | (S)-VERAPAMIL | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | GNF-PF-2893 | CHEMBL312032 | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | SB-222200 | SB-222200 | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | DEXPROPRANOLOL | DEXPROPRANOLOL | |
7253 | TSHR | CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE | | CLOTRIMAZOLE | CLOTRIMAZOLE | |