![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM263 |
Gene summary for TMEM263 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM263 | Gene ID | 90488 |
Gene name | transmembrane protein 263 | |
Gene Alias | C12orf23 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WUH6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90488 | TMEM263 | LZE4T | Human | Esophagus | ESCC | 4.53e-03 | 2.37e-01 | 0.0811 |
90488 | TMEM263 | LZE20T | Human | Esophagus | ESCC | 8.75e-06 | 1.68e-01 | 0.0662 |
90488 | TMEM263 | LZE22D1 | Human | Esophagus | HGIN | 1.55e-02 | 4.76e-02 | 0.0595 |
90488 | TMEM263 | LZE22T | Human | Esophagus | ESCC | 4.59e-06 | 4.96e-01 | 0.068 |
90488 | TMEM263 | LZE24T | Human | Esophagus | ESCC | 1.34e-21 | 3.89e-01 | 0.0596 |
90488 | TMEM263 | P1T-E | Human | Esophagus | ESCC | 8.90e-07 | 3.91e-01 | 0.0875 |
90488 | TMEM263 | P2T-E | Human | Esophagus | ESCC | 1.05e-61 | 1.14e+00 | 0.1177 |
90488 | TMEM263 | P4T-E | Human | Esophagus | ESCC | 7.49e-24 | 5.85e-01 | 0.1323 |
90488 | TMEM263 | P5T-E | Human | Esophagus | ESCC | 8.81e-12 | 2.69e-01 | 0.1327 |
90488 | TMEM263 | P8T-E | Human | Esophagus | ESCC | 5.95e-32 | 6.99e-01 | 0.0889 |
90488 | TMEM263 | P9T-E | Human | Esophagus | ESCC | 7.32e-10 | 3.87e-01 | 0.1131 |
90488 | TMEM263 | P10T-E | Human | Esophagus | ESCC | 3.95e-29 | 7.08e-01 | 0.116 |
90488 | TMEM263 | P11T-E | Human | Esophagus | ESCC | 4.08e-24 | 1.14e+00 | 0.1426 |
90488 | TMEM263 | P12T-E | Human | Esophagus | ESCC | 6.13e-21 | 4.81e-01 | 0.1122 |
90488 | TMEM263 | P15T-E | Human | Esophagus | ESCC | 2.21e-12 | 3.69e-01 | 0.1149 |
90488 | TMEM263 | P16T-E | Human | Esophagus | ESCC | 4.23e-37 | 7.36e-01 | 0.1153 |
90488 | TMEM263 | P17T-E | Human | Esophagus | ESCC | 2.32e-05 | 4.75e-01 | 0.1278 |
90488 | TMEM263 | P19T-E | Human | Esophagus | ESCC | 1.15e-10 | 8.46e-01 | 0.1662 |
90488 | TMEM263 | P20T-E | Human | Esophagus | ESCC | 9.10e-09 | 2.98e-01 | 0.1124 |
90488 | TMEM263 | P21T-E | Human | Esophagus | ESCC | 1.76e-24 | 5.73e-01 | 0.1617 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM263 | SNV | Missense_Mutation | novel | c.139N>G | p.Lys47Glu | p.K47E | Q8WUH6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.908) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM263 | SNV | Missense_Mutation | c.206A>C | p.Lys69Thr | p.K69T | Q8WUH6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM263 | SNV | Missense_Mutation | c.266N>G | p.Ala89Gly | p.A89G | Q8WUH6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.931) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | |
TMEM263 | SNV | Missense_Mutation | novel | c.223N>A | p.Val75Met | p.V75M | Q8WUH6 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.972) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |