GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00425938 | Breast | Precancer | glucose homeostasis | 31/1080 | 258/18723 | 8.89e-05 | 1.69e-03 | 31 |
GO:00335008 | Breast | Precancer | carbohydrate homeostasis | 31/1080 | 259/18723 | 9.56e-05 | 1.79e-03 | 31 |
GO:19012169 | Breast | Precancer | positive regulation of neuron death | 16/1080 | 97/18723 | 1.29e-04 | 2.24e-03 | 16 |
GO:00508789 | Breast | Precancer | regulation of body fluid levels | 40/1080 | 379/18723 | 1.68e-04 | 2.77e-03 | 40 |
GO:00094108 | Breast | Precancer | response to xenobiotic stimulus | 45/1080 | 462/18723 | 4.17e-04 | 5.56e-03 | 45 |
GO:00435258 | Breast | Precancer | positive regulation of neuron apoptotic process | 11/1080 | 58/18723 | 4.17e-04 | 5.56e-03 | 11 |
GO:00435243 | Breast | Precancer | negative regulation of neuron apoptotic process | 19/1080 | 145/18723 | 6.83e-04 | 8.34e-03 | 19 |
GO:00454444 | Breast | Precancer | fat cell differentiation | 26/1080 | 229/18723 | 7.60e-04 | 9.04e-03 | 26 |
GO:19012157 | Breast | Precancer | negative regulation of neuron death | 24/1080 | 208/18723 | 9.50e-04 | 1.07e-02 | 24 |
GO:00060066 | Breast | Precancer | glucose metabolic process | 23/1080 | 196/18723 | 9.54e-04 | 1.07e-02 | 23 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:00059966 | Breast | Precancer | monosaccharide metabolic process | 27/1080 | 257/18723 | 1.94e-03 | 1.88e-02 | 27 |
GO:00193186 | Breast | Precancer | hexose metabolic process | 25/1080 | 237/18723 | 2.64e-03 | 2.36e-02 | 25 |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00900875 | Breast | Precancer | regulation of peptide transport | 22/1080 | 202/18723 | 3.14e-03 | 2.65e-02 | 22 |
GO:00300736 | Breast | Precancer | insulin secretion | 21/1080 | 195/18723 | 4.38e-03 | 3.42e-02 | 21 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TFAP2B | INCAF | Oral cavity | ADJ | IGFBP2,C10orf10,SLC5A3, etc. | 1.06e-01 | |
TFAP2B | CAF | Oral cavity | ADJ | IGFBP2,C10orf10,SLC5A3, etc. | 4.28e-02 | |
TFAP2B | ICAF | Oral cavity | LP | IGFBP2,C10orf10,SLC5A3, etc. | 1.77e-01 | |
TFAP2B | INCAF | Oral cavity | LP | IGFBP2,C10orf10,SLC5A3, etc. | 4.44e-01 | |
TFAP2B | ICAF | Oral cavity | OSCC | IGFBP2,C10orf10,SLC5A3, etc. | 2.41e-01 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFAP2B | SNV | Missense_Mutation | | c.585G>C | p.Gln195His | p.Q195H | Q92481 | protein_coding | tolerated(0.08) | probably_damaging(0.965) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TFAP2B | SNV | Missense_Mutation | | c.629C>T | p.Ser210Phe | p.S210F | Q92481 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD |
TFAP2B | SNV | Missense_Mutation | | c.1375N>G | p.Arg459Gly | p.R459G | Q92481 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-C8-A12Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFAP2B | SNV | Missense_Mutation | | c.847N>G | p.Ser283Ala | p.S283A | Q92481 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-D8-A27R-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin+cyclophosphamide | SD |
TFAP2B | SNV | Missense_Mutation | novel | c.839G>A | p.Gly280Glu | p.G280E | Q92481 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A1LE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | PD |
TFAP2B | insertion | In_Frame_Ins | novel | c.1343_1344insAAATCGTTGTGATTGTTGTGCTCT | p.Gly448_Ser449insAsnArgCysAspCysCysAlaLeu | p.G448_S449insNRCDCCAL | Q92481 | protein_coding | | | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFAP2B | insertion | Frame_Shift_Ins | novel | c.1345_1346insT | p.Ser449MetfsTer2 | p.S449Mfs*2 | Q92481 | protein_coding | | | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFAP2B | deletion | Frame_Shift_Del | novel | c.786delN | p.Leu263SerfsTer26 | p.L263Sfs*26 | Q92481 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
TFAP2B | insertion | Frame_Shift_Ins | novel | c.836dupA | p.Asn279LysfsTer43 | p.N279Kfs*43 | Q92481 | protein_coding | | | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFAP2B | SNV | Missense_Mutation | | c.640A>G | p.Asn214Asp | p.N214D | Q92481 | protein_coding | tolerated(0.08) | benign(0.051) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD |