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Gene: STYK1 |
Gene summary for STYK1 |
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Gene information | Species | Human | Gene symbol | STYK1 | Gene ID | 55359 |
Gene name | serine/threonine/tyrosine kinase 1 | |
Gene Alias | NOK | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q6J9G0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55359 | STYK1 | CCI_1 | Human | Cervix | CC | 1.50e-10 | 7.46e-01 | 0.528 |
55359 | STYK1 | CCI_2 | Human | Cervix | CC | 2.16e-02 | 3.46e-01 | 0.5249 |
55359 | STYK1 | CCI_3 | Human | Cervix | CC | 3.64e-06 | 5.62e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STYK1 | SNV | Missense_Mutation | rs554694983 | c.1109N>A | p.Arg370His | p.R370H | Q6J9G0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STYK1 | SNV | Missense_Mutation | rs368292071 | c.890N>A | p.Arg297Gln | p.R297Q | Q6J9G0 | protein_coding | tolerated(0.28) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STYK1 | SNV | Missense_Mutation | c.856N>G | p.Gln286Glu | p.Q286E | Q6J9G0 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
STYK1 | SNV | Missense_Mutation | novel | c.1179N>T | p.Leu393Phe | p.L393F | Q6J9G0 | protein_coding | deleterious(0.01) | benign(0.066) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.349N>G | p.Leu117Val | p.L117V | Q6J9G0 | protein_coding | tolerated(0.06) | benign(0.111) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
STYK1 | SNV | Missense_Mutation | rs375423751 | c.1091N>A | p.Arg364His | p.R364H | Q6J9G0 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
STYK1 | SNV | Missense_Mutation | rs375423751 | c.1091N>A | p.Arg364His | p.R364H | Q6J9G0 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
STYK1 | SNV | Missense_Mutation | c.127G>A | p.Val43Ile | p.V43I | Q6J9G0 | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
STYK1 | SNV | Missense_Mutation | c.713N>T | p.Ala238Val | p.A238V | Q6J9G0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
STYK1 | SNV | Missense_Mutation | rs746426634 | c.326N>T | p.Pro109Leu | p.P109L | Q6J9G0 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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