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Gene: SPATA24 |
Gene summary for SPATA24 |
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Gene information | Species | Human | Gene symbol | SPATA24 | Gene ID | 202051 |
Gene name | spermatogenesis associated 24 | |
Gene Alias | CCDC161 | |
Cytomap | 5q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86W54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
202051 | SPATA24 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.09e-05 | 2.22e-01 | -0.1808 |
202051 | SPATA24 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.86e-02 | 1.78e-01 | -0.0811 |
202051 | SPATA24 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.68e-11 | 3.46e-01 | -0.1088 |
202051 | SPATA24 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.64e-19 | 4.60e-01 | -0.1954 |
202051 | SPATA24 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.70e-06 | 5.81e-01 | -0.2602 |
202051 | SPATA24 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.54e-03 | 3.77e-01 | -0.2196 |
202051 | SPATA24 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.14e-08 | 3.70e-01 | -0.1207 |
202051 | SPATA24 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.62e-25 | 5.40e-01 | -0.1464 |
202051 | SPATA24 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.46e-14 | 3.40e-01 | -0.1001 |
202051 | SPATA24 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.82e-03 | 1.56e-01 | -0.059 |
202051 | SPATA24 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.33e-02 | 2.82e-01 | -0.2061 |
202051 | SPATA24 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.29e-04 | 3.43e-01 | -0.1462 |
202051 | SPATA24 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.09e-07 | 3.96e-01 | -0.0842 |
202051 | SPATA24 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.22e-04 | 3.33e-01 | -0.0177 |
202051 | SPATA24 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.20e-02 | 1.73e-01 | 0.0338 |
202051 | SPATA24 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.71e-02 | 8.92e-02 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA24 | SNV | Missense_Mutation | c.133N>A | p.Glu45Lys | p.E45K | Q86W54 | protein_coding | tolerated(0.09) | probably_damaging(0.988) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
SPATA24 | SNV | Missense_Mutation | novel | c.189N>T | p.Glu63Asp | p.E63D | Q86W54 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SPATA24 | SNV | Missense_Mutation | c.159C>A | p.Phe53Leu | p.F53L | Q86W54 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPATA24 | SNV | Missense_Mutation | c.256G>A | p.Gly86Arg | p.G86R | Q86W54 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
SPATA24 | SNV | Missense_Mutation | rs192704505 | c.163N>A | p.Ala55Thr | p.A55T | Q86W54 | protein_coding | tolerated(0.25) | benign(0.214) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SPATA24 | SNV | Missense_Mutation | rs745716164 | c.224N>T | p.Ala75Val | p.A75V | Q86W54 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPATA24 | SNV | Missense_Mutation | novel | c.399N>A | p.His133Gln | p.H133Q | Q86W54 | protein_coding | tolerated(0.38) | probably_damaging(0.986) | TCGA-AX-A3FZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SPATA24 | SNV | Missense_Mutation | c.217N>A | p.Leu73Ile | p.L73I | Q86W54 | protein_coding | tolerated(0.24) | possibly_damaging(0.879) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPATA24 | SNV | Missense_Mutation | novel | c.533N>G | p.Tyr178Cys | p.Y178C | Q86W54 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPATA24 | SNV | Missense_Mutation | novel | c.106C>A | p.Leu36Met | p.L36M | Q86W54 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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