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Gene: SLC16A11 |
Gene summary for SLC16A11 |
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Gene information | Species | Human | Gene symbol | SLC16A11 | Gene ID | 162515 |
Gene name | solute carrier family 16 member 11 | |
Gene Alias | MCT 11 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q8NCK7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162515 | SLC16A11 | LZE4T | Human | Esophagus | ESCC | 1.20e-04 | 1.58e-01 | 0.0811 |
162515 | SLC16A11 | LZE7T | Human | Esophagus | ESCC | 3.90e-02 | 1.25e-01 | 0.0667 |
162515 | SLC16A11 | LZE24T | Human | Esophagus | ESCC | 1.46e-02 | 9.19e-02 | 0.0596 |
162515 | SLC16A11 | P2T-E | Human | Esophagus | ESCC | 1.16e-08 | 1.80e-01 | 0.1177 |
162515 | SLC16A11 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.62e-01 | 0.1323 |
162515 | SLC16A11 | P8T-E | Human | Esophagus | ESCC | 2.76e-09 | 1.28e-01 | 0.0889 |
162515 | SLC16A11 | P9T-E | Human | Esophagus | ESCC | 1.88e-05 | 1.35e-01 | 0.1131 |
162515 | SLC16A11 | P10T-E | Human | Esophagus | ESCC | 1.38e-11 | 2.32e-01 | 0.116 |
162515 | SLC16A11 | P12T-E | Human | Esophagus | ESCC | 1.08e-15 | 3.04e-01 | 0.1122 |
162515 | SLC16A11 | P16T-E | Human | Esophagus | ESCC | 2.36e-07 | 1.45e-01 | 0.1153 |
162515 | SLC16A11 | P22T-E | Human | Esophagus | ESCC | 3.01e-17 | 3.93e-01 | 0.1236 |
162515 | SLC16A11 | P26T-E | Human | Esophagus | ESCC | 4.21e-13 | 2.73e-01 | 0.1276 |
162515 | SLC16A11 | P27T-E | Human | Esophagus | ESCC | 1.57e-11 | 1.63e-01 | 0.1055 |
162515 | SLC16A11 | P30T-E | Human | Esophagus | ESCC | 1.72e-15 | 5.23e-01 | 0.137 |
162515 | SLC16A11 | P49T-E | Human | Esophagus | ESCC | 5.57e-05 | 5.04e-01 | 0.1768 |
162515 | SLC16A11 | P57T-E | Human | Esophagus | ESCC | 2.89e-06 | 8.54e-02 | 0.0926 |
162515 | SLC16A11 | P76T-E | Human | Esophagus | ESCC | 9.46e-09 | 1.11e-01 | 0.1207 |
162515 | SLC16A11 | P107T-E | Human | Esophagus | ESCC | 8.98e-03 | 8.24e-02 | 0.171 |
162515 | SLC16A11 | P130T-E | Human | Esophagus | ESCC | 3.49e-02 | 3.92e-02 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC16A11 | SNV | Missense_Mutation | c.929N>A | p.Arg310Gln | p.R310Q | Q8NCK7 | protein_coding | tolerated(0.05) | probably_damaging(0.946) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC16A11 | SNV | Missense_Mutation | c.811G>C | p.Asp271His | p.D271H | Q8NCK7 | protein_coding | tolerated(0.12) | benign(0.411) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC16A11 | SNV | Missense_Mutation | novel | c.440T>C | p.Phe147Ser | p.F147S | Q8NCK7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SLC16A11 | SNV | Missense_Mutation | c.400G>A | p.Gly134Ser | p.G134S | Q8NCK7 | protein_coding | tolerated(1) | possibly_damaging(0.876) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC16A11 | deletion | Frame_Shift_Del | c.310delG | p.Ala104ProfsTer5 | p.A104Pfs*5 | Q8NCK7 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SLC16A11 | SNV | Missense_Mutation | novel | c.595N>A | p.Leu199Ile | p.L199I | Q8NCK7 | protein_coding | tolerated(0.69) | benign(0.119) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC16A11 | SNV | Missense_Mutation | novel | c.202N>A | p.Glu68Lys | p.E68K | Q8NCK7 | protein_coding | tolerated(0.21) | probably_damaging(0.919) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC16A11 | SNV | Missense_Mutation | c.1210G>T | p.Asp404Tyr | p.D404Y | Q8NCK7 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SLC16A11 | SNV | Missense_Mutation | novel | c.1357C>T | p.Pro453Ser | p.P453S | Q8NCK7 | protein_coding | tolerated(0.06) | benign(0.081) | TCGA-AX-A2H4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
SLC16A11 | SNV | Missense_Mutation | c.1219N>A | p.Ala407Thr | p.A407T | Q8NCK7 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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