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Gene: SFRP1 |
Gene summary for SFRP1 |
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Gene information | Species | Human | Gene symbol | SFRP1 | Gene ID | 6422 |
Gene name | secreted frizzled related protein 1 | |
Gene Alias | FRP | |
Cytomap | 8p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8N474 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6422 | SFRP1 | GSM4909281 | Human | Breast | IDC | 3.65e-14 | -5.99e-01 | 0.21 |
6422 | SFRP1 | GSM4909282 | Human | Breast | IDC | 3.92e-06 | 3.22e-01 | -0.0288 |
6422 | SFRP1 | GSM4909285 | Human | Breast | IDC | 1.08e-22 | -6.60e-01 | 0.21 |
6422 | SFRP1 | GSM4909286 | Human | Breast | IDC | 4.48e-10 | -2.24e-01 | 0.1081 |
6422 | SFRP1 | GSM4909290 | Human | Breast | IDC | 5.68e-41 | -1.06e+00 | 0.2096 |
6422 | SFRP1 | GSM4909291 | Human | Breast | IDC | 2.53e-34 | -1.06e+00 | 0.1753 |
6422 | SFRP1 | GSM4909292 | Human | Breast | IDC | 4.95e-06 | -1.03e+00 | 0.1236 |
6422 | SFRP1 | GSM4909293 | Human | Breast | IDC | 1.98e-30 | -7.28e-01 | 0.1581 |
6422 | SFRP1 | GSM4909294 | Human | Breast | IDC | 3.65e-51 | -9.71e-01 | 0.2022 |
6422 | SFRP1 | GSM4909296 | Human | Breast | IDC | 1.65e-49 | -1.03e+00 | 0.1524 |
6422 | SFRP1 | GSM4909297 | Human | Breast | IDC | 9.17e-45 | -9.94e-01 | 0.1517 |
6422 | SFRP1 | GSM4909298 | Human | Breast | IDC | 9.89e-35 | -8.24e-01 | 0.1551 |
6422 | SFRP1 | GSM4909299 | Human | Breast | IDC | 1.75e-08 | 4.47e-01 | 0.035 |
6422 | SFRP1 | GSM4909301 | Human | Breast | IDC | 7.38e-56 | -1.05e+00 | 0.1577 |
6422 | SFRP1 | GSM4909302 | Human | Breast | IDC | 8.32e-40 | -9.56e-01 | 0.1545 |
6422 | SFRP1 | GSM4909304 | Human | Breast | IDC | 3.77e-60 | -1.06e+00 | 0.1636 |
6422 | SFRP1 | GSM4909306 | Human | Breast | IDC | 2.55e-24 | -6.21e-01 | 0.1564 |
6422 | SFRP1 | GSM4909307 | Human | Breast | IDC | 1.33e-20 | -6.60e-01 | 0.1569 |
6422 | SFRP1 | GSM4909308 | Human | Breast | IDC | 1.95e-46 | -1.06e+00 | 0.158 |
6422 | SFRP1 | GSM4909311 | Human | Breast | IDC | 7.18e-39 | -8.75e-01 | 0.1534 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00362948 | Breast | Precancer | cellular response to decreased oxygen levels | 31/1080 | 161/18723 | 2.61e-09 | 2.11e-07 | 31 |
GO:00714538 | Breast | Precancer | cellular response to oxygen levels | 32/1080 | 177/18723 | 7.32e-09 | 5.52e-07 | 32 |
GO:00714565 | Breast | Precancer | cellular response to hypoxia | 29/1080 | 151/18723 | 8.98e-09 | 6.50e-07 | 29 |
GO:00309018 | Breast | Precancer | midbrain development | 20/1080 | 90/18723 | 1.50e-07 | 7.93e-06 | 20 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:00436273 | Breast | Precancer | response to estrogen | 15/1080 | 75/18723 | 2.06e-05 | 4.83e-04 | 15 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:00456379 | Breast | Precancer | regulation of myeloid cell differentiation | 28/1080 | 210/18723 | 3.05e-05 | 6.72e-04 | 28 |
GO:19037069 | Breast | Precancer | regulation of hemopoiesis | 41/1080 | 367/18723 | 3.95e-05 | 8.52e-04 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431016 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431023 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
hsa0431033 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFRP1 | SNV | Missense_Mutation | rs765603358 | c.934G>A | p.Val312Met | p.V312M | Q8N474 | protein_coding | deleterious(0.02) | possibly_damaging(0.721) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SFRP1 | SNV | Missense_Mutation | c.262G>A | p.Ala88Thr | p.A88T | Q8N474 | protein_coding | tolerated(0.17) | benign(0.062) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SFRP1 | SNV | Missense_Mutation | novel | c.153C>G | p.Phe51Leu | p.F51L | Q8N474 | protein_coding | tolerated(0.31) | benign(0.041) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SFRP1 | SNV | Missense_Mutation | novel | c.97G>A | p.Glu33Lys | p.E33K | Q8N474 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SFRP1 | SNV | Missense_Mutation | c.400G>A | p.Glu134Lys | p.E134K | Q8N474 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFRP1 | SNV | Missense_Mutation | rs761465184 | c.845N>T | p.Thr282Met | p.T282M | Q8N474 | protein_coding | tolerated(0.19) | benign(0.354) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SFRP1 | SNV | Missense_Mutation | c.383C>T | p.Pro128Leu | p.P128L | Q8N474 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
SFRP1 | SNV | Missense_Mutation | c.103N>A | p.Asp35Asn | p.D35N | Q8N474 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFRP1 | SNV | Missense_Mutation | novel | c.457N>A | p.Glu153Lys | p.E153K | Q8N474 | protein_coding | tolerated(0.05) | benign(0.338) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SFRP1 | SNV | Missense_Mutation | novel | c.629G>T | p.Arg210Met | p.R210M | Q8N474 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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