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Gene: RQCD1 |
Gene summary for RQCD1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RQCD1 | Gene ID | 9125 |
Gene name | CCR4-NOT transcription complex subunit 9 | |
Gene Alias | CAF40 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q92600 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9125 | RQCD1 | P1T-E | Human | Esophagus | ESCC | 2.44e-06 | 2.41e-01 | 0.0875 |
9125 | RQCD1 | P2T-E | Human | Esophagus | ESCC | 1.00e-24 | 4.54e-01 | 0.1177 |
9125 | RQCD1 | P4T-E | Human | Esophagus | ESCC | 4.59e-20 | 4.09e-01 | 0.1323 |
9125 | RQCD1 | P5T-E | Human | Esophagus | ESCC | 8.73e-28 | 5.40e-01 | 0.1327 |
9125 | RQCD1 | P8T-E | Human | Esophagus | ESCC | 6.56e-15 | 3.23e-01 | 0.0889 |
9125 | RQCD1 | P9T-E | Human | Esophagus | ESCC | 5.74e-10 | 2.47e-01 | 0.1131 |
9125 | RQCD1 | P10T-E | Human | Esophagus | ESCC | 7.52e-23 | 4.37e-01 | 0.116 |
9125 | RQCD1 | P11T-E | Human | Esophagus | ESCC | 2.94e-14 | 4.78e-01 | 0.1426 |
9125 | RQCD1 | P12T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.56e-01 | 0.1122 |
9125 | RQCD1 | P15T-E | Human | Esophagus | ESCC | 3.71e-26 | 5.48e-01 | 0.1149 |
9125 | RQCD1 | P16T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.64e-01 | 0.1153 |
9125 | RQCD1 | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 2.69e-01 | 0.1278 |
9125 | RQCD1 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.76e-01 | 0.1662 |
9125 | RQCD1 | P20T-E | Human | Esophagus | ESCC | 1.39e-16 | 3.47e-01 | 0.1124 |
9125 | RQCD1 | P21T-E | Human | Esophagus | ESCC | 2.08e-40 | 7.71e-01 | 0.1617 |
9125 | RQCD1 | P22T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.24e-01 | 0.1236 |
9125 | RQCD1 | P23T-E | Human | Esophagus | ESCC | 4.70e-20 | 3.69e-01 | 0.108 |
9125 | RQCD1 | P24T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.64e-01 | 0.1287 |
9125 | RQCD1 | P26T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.02e-01 | 0.1276 |
9125 | RQCD1 | P27T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.30e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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