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Gene: RPS27AP16 |
Gene summary for RPS27AP16 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPS27AP16 | Gene ID | 643358 |
Gene name | RPS27A pseudogene 16 | |
Gene Alias | RPS27A_8_1488 | |
Cytomap | 16q21 | |
Gene Type | pseudo | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
643358 | RPS27AP16 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 3.77e-15 | -6.41e-01 | 0.02 |
643358 | RPS27AP16 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 1.85e-11 | -6.41e-01 | 0.0267 |
643358 | RPS27AP16 | PTCwithHT_1 | Human | Thyroid | HT | 9.83e-04 | -6.41e-01 | 0.0238 |
643358 | RPS27AP16 | PTCwithHT_6 | Human | Thyroid | HT | 8.48e-15 | -6.41e-01 | 0.02 |
643358 | RPS27AP16 | PTCwithHT_8 | Human | Thyroid | HT | 3.77e-15 | -6.41e-01 | 0.0351 |
643358 | RPS27AP16 | PTCwithoutHT_2 | Human | Thyroid | PTC | 3.77e-15 | -6.41e-01 | 0.0419 |
643358 | RPS27AP16 | PTCwithoutHT_7 | Human | Thyroid | PTC | 9.83e-04 | -6.41e-01 | 0.0381 |
643358 | RPS27AP16 | male-WTA | Human | Thyroid | PTC | 2.06e-49 | -2.39e-01 | 0.1037 |
643358 | RPS27AP16 | nodule-WTA | Human | Thyroid | goiters | 2.51e-02 | -5.01e-01 | 0.0534 |
643358 | RPS27AP16 | PTC01 | Human | Thyroid | PTC | 9.50e-14 | -6.41e-01 | 0.1899 |
643358 | RPS27AP16 | PTC03 | Human | Thyroid | PTC | 1.37e-03 | -6.41e-01 | 0.1784 |
643358 | RPS27AP16 | PTC04 | Human | Thyroid | PTC | 3.77e-15 | -6.41e-01 | 0.1927 |
643358 | RPS27AP16 | PTC05 | Human | Thyroid | PTC | 8.34e-04 | -6.41e-01 | 0.2065 |
643358 | RPS27AP16 | PTC06 | Human | Thyroid | PTC | 1.90e-09 | -6.41e-01 | 0.2057 |
643358 | RPS27AP16 | PTC07 | Human | Thyroid | PTC | 4.25e-14 | -6.41e-01 | 0.2044 |
643358 | RPS27AP16 | ATC08 | Human | Thyroid | ATC | 2.67e-03 | -6.41e-01 | 0.0541 |
643358 | RPS27AP16 | ATC09 | Human | Thyroid | ATC | 5.11e-04 | -6.41e-01 | 0.2871 |
643358 | RPS27AP16 | ATC12 | Human | Thyroid | ATC | 1.68e-15 | -6.41e-01 | 0.34 |
643358 | RPS27AP16 | ATC13 | Human | Thyroid | ATC | 1.68e-15 | -6.41e-01 | 0.34 |
643358 | RPS27AP16 | ATC1 | Human | Thyroid | ATC | 5.24e-03 | -6.41e-01 | 0.2878 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ATC: Anaplastic thyroid cancer | |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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