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Gene: RMDN3 |
Gene summary for RMDN3 |
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Gene information | Species | Human | Gene symbol | RMDN3 | Gene ID | 55177 |
Gene name | regulator of microtubule dynamics 3 | |
Gene Alias | FAM82A2 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | A0A024R9P6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55177 | RMDN3 | LZE4T | Human | Esophagus | ESCC | 3.16e-10 | 2.24e-01 | 0.0811 |
55177 | RMDN3 | LZE22T | Human | Esophagus | ESCC | 1.60e-02 | 2.33e-01 | 0.068 |
55177 | RMDN3 | LZE24T | Human | Esophagus | ESCC | 1.69e-10 | 3.46e-01 | 0.0596 |
55177 | RMDN3 | P1T-E | Human | Esophagus | ESCC | 2.04e-11 | 6.36e-01 | 0.0875 |
55177 | RMDN3 | P2T-E | Human | Esophagus | ESCC | 8.94e-11 | 2.06e-01 | 0.1177 |
55177 | RMDN3 | P4T-E | Human | Esophagus | ESCC | 5.68e-17 | 4.28e-01 | 0.1323 |
55177 | RMDN3 | P5T-E | Human | Esophagus | ESCC | 2.34e-11 | 3.01e-01 | 0.1327 |
55177 | RMDN3 | P8T-E | Human | Esophagus | ESCC | 1.44e-36 | 6.39e-01 | 0.0889 |
55177 | RMDN3 | P9T-E | Human | Esophagus | ESCC | 2.07e-12 | 3.10e-01 | 0.1131 |
55177 | RMDN3 | P10T-E | Human | Esophagus | ESCC | 5.93e-31 | 5.61e-01 | 0.116 |
55177 | RMDN3 | P11T-E | Human | Esophagus | ESCC | 1.89e-11 | 4.03e-01 | 0.1426 |
55177 | RMDN3 | P12T-E | Human | Esophagus | ESCC | 1.06e-28 | 5.16e-01 | 0.1122 |
55177 | RMDN3 | P15T-E | Human | Esophagus | ESCC | 2.78e-21 | 5.04e-01 | 0.1149 |
55177 | RMDN3 | P16T-E | Human | Esophagus | ESCC | 6.96e-18 | 3.93e-01 | 0.1153 |
55177 | RMDN3 | P17T-E | Human | Esophagus | ESCC | 2.46e-02 | 3.26e-01 | 0.1278 |
55177 | RMDN3 | P20T-E | Human | Esophagus | ESCC | 1.64e-15 | 3.15e-01 | 0.1124 |
55177 | RMDN3 | P21T-E | Human | Esophagus | ESCC | 1.25e-22 | 4.32e-01 | 0.1617 |
55177 | RMDN3 | P22T-E | Human | Esophagus | ESCC | 5.68e-21 | 3.00e-01 | 0.1236 |
55177 | RMDN3 | P23T-E | Human | Esophagus | ESCC | 1.67e-25 | 6.74e-01 | 0.108 |
55177 | RMDN3 | P24T-E | Human | Esophagus | ESCC | 9.24e-16 | 3.85e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RMDN3 | SNV | Missense_Mutation | c.487N>G | p.Ser163Ala | p.S163A | Q96TC7 | protein_coding | tolerated(0.16) | benign(0.203) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
RMDN3 | SNV | Missense_Mutation | c.556N>A | p.Glu186Lys | p.E186K | Q96TC7 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
RMDN3 | SNV | Missense_Mutation | novel | c.568G>A | p.Asp190Asn | p.D190N | Q96TC7 | protein_coding | deleterious(0.01) | benign(0.426) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RMDN3 | insertion | Nonsense_Mutation | novel | c.571_572insGCTTCCTGTGGGAAGGTGACTGACTG | p.Lys191SerfsTer8 | p.K191Sfs*8 | Q96TC7 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RMDN3 | insertion | Frame_Shift_Ins | novel | c.1179_1180insTG | p.Pro394CysfsTer15 | p.P394Cfs*15 | Q96TC7 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RMDN3 | insertion | Nonsense_Mutation | novel | c.1178_1179insGAGGTAAGGCTTTTTAATA | p.Ser393ArgfsTer3 | p.S393Rfs*3 | Q96TC7 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RMDN3 | insertion | Frame_Shift_Ins | novel | c.1158_1159insTTTCCCAGGCTGAAGAACTACAGCCAGGATTTTCCAAAGCAGGAAGG | p.Ala387PhefsTer37 | p.A387Ffs*37 | Q96TC7 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
RMDN3 | deletion | Frame_Shift_Del | c.735delN | p.Asp246ThrfsTer49 | p.D246Tfs*49 | Q96TC7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
RMDN3 | SNV | Missense_Mutation | novel | c.671N>G | p.Ser224Cys | p.S224C | Q96TC7 | protein_coding | deleterious(0.05) | benign(0.151) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RMDN3 | SNV | Missense_Mutation | novel | c.514N>G | p.Ser172Gly | p.S172G | Q96TC7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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