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Gene: RBM34 |
Gene summary for RBM34 |
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Gene information | Species | Human | Gene symbol | RBM34 | Gene ID | 23029 |
Gene name | RNA binding motif protein 34 | |
Gene Alias | RBM34 | |
Cytomap | 1q42.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P42696 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23029 | RBM34 | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.07e-01 | 0.082 |
23029 | RBM34 | LZE4T | Human | Esophagus | ESCC | 3.18e-05 | 1.54e-01 | 0.0811 |
23029 | RBM34 | LZE7T | Human | Esophagus | ESCC | 4.33e-11 | 3.91e-01 | 0.0667 |
23029 | RBM34 | LZE22T | Human | Esophagus | ESCC | 1.48e-05 | 3.54e-01 | 0.068 |
23029 | RBM34 | LZE24T | Human | Esophagus | ESCC | 6.88e-12 | 2.64e-01 | 0.0596 |
23029 | RBM34 | P1T-E | Human | Esophagus | ESCC | 7.43e-09 | 3.90e-01 | 0.0875 |
23029 | RBM34 | P2T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.78e-01 | 0.1177 |
23029 | RBM34 | P4T-E | Human | Esophagus | ESCC | 1.36e-04 | 1.42e-01 | 0.1323 |
23029 | RBM34 | P5T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.53e-01 | 0.1327 |
23029 | RBM34 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.87e-02 | 0.0889 |
23029 | RBM34 | P9T-E | Human | Esophagus | ESCC | 2.38e-11 | 2.38e-01 | 0.1131 |
23029 | RBM34 | P10T-E | Human | Esophagus | ESCC | 6.62e-20 | 4.07e-01 | 0.116 |
23029 | RBM34 | P11T-E | Human | Esophagus | ESCC | 3.75e-08 | 2.58e-01 | 0.1426 |
23029 | RBM34 | P12T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.48e-01 | 0.1122 |
23029 | RBM34 | P15T-E | Human | Esophagus | ESCC | 7.99e-08 | 1.95e-01 | 0.1149 |
23029 | RBM34 | P16T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.63e-01 | 0.1153 |
23029 | RBM34 | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 1.98e-01 | 0.1278 |
23029 | RBM34 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.42e-01 | 0.1662 |
23029 | RBM34 | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 2.83e-01 | 0.1124 |
23029 | RBM34 | P21T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.99e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM34 | SNV | Missense_Mutation | novel | c.1096N>C | p.Glu366Gln | p.E366Q | P42696 | protein_coding | tolerated(0.06) | benign(0.065) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
RBM34 | SNV | Missense_Mutation | c.1242N>C | p.Lys414Asn | p.K414N | P42696 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
RBM34 | SNV | Missense_Mutation | c.811N>C | p.Phe271Leu | p.F271L | P42696 | protein_coding | deleterious(0) | benign(0.076) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
RBM34 | SNV | Missense_Mutation | rs761837567 | c.1082G>A | p.Arg361His | p.R361H | P42696 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RBM34 | SNV | Missense_Mutation | rs752241692 | c.373G>A | p.Ala125Thr | p.A125T | P42696 | protein_coding | deleterious(0.04) | benign(0.154) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RBM34 | SNV | Missense_Mutation | novel | c.437N>A | p.Ser146Tyr | p.S146Y | P42696 | protein_coding | deleterious(0) | benign(0.175) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RBM34 | SNV | Missense_Mutation | novel | c.1199N>T | p.Ser400Ile | p.S400I | P42696 | protein_coding | deleterious(0.01) | benign(0.271) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM34 | SNV | Missense_Mutation | c.203N>G | p.Gln68Arg | p.Q68R | P42696 | protein_coding | tolerated(0.36) | benign(0.006) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RBM34 | SNV | Missense_Mutation | c.1264C>T | p.Arg422Cys | p.R422C | P42696 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
RBM34 | SNV | Missense_Mutation | c.571A>G | p.Asn191Asp | p.N191D | P42696 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6509-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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