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Gene: PLEKHS1 |
Gene summary for PLEKHS1 |
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Gene information | Species | Human | Gene symbol | PLEKHS1 | Gene ID | 79949 |
Gene name | pleckstrin homology domain containing S1 | |
Gene Alias | C10orf81 | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5SXH7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79949 | PLEKHS1 | P8T-E | Human | Esophagus | ESCC | 2.15e-31 | 7.88e-01 | 0.0889 |
79949 | PLEKHS1 | P23T-E | Human | Esophagus | ESCC | 3.75e-09 | 4.45e-01 | 0.108 |
79949 | PLEKHS1 | P24T-E | Human | Esophagus | ESCC | 2.21e-02 | 8.74e-02 | 0.1287 |
79949 | PLEKHS1 | P54T-E | Human | Esophagus | ESCC | 1.09e-06 | 2.60e-01 | 0.0975 |
79949 | PLEKHS1 | P57T-E | Human | Esophagus | ESCC | 2.34e-18 | 4.17e-01 | 0.0926 |
79949 | PLEKHS1 | P76T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.95e-01 | 0.1207 |
79949 | PLEKHS1 | P82T-E | Human | Esophagus | ESCC | 3.97e-03 | 2.78e-01 | 0.1072 |
79949 | PLEKHS1 | P127T-E | Human | Esophagus | ESCC | 2.91e-02 | -4.28e-03 | 0.0826 |
79949 | PLEKHS1 | P128T-E | Human | Esophagus | ESCC | 9.19e-17 | 9.18e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHS1 | SNV | Missense_Mutation | novel | c.443N>T | p.Arg148Ile | p.R148I | Q5SXH7 | protein_coding | deleterious(0.03) | probably_damaging(0.974) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHS1 | SNV | Missense_Mutation | novel | c.26N>G | p.Phe9Cys | p.F9C | Q5SXH7 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PLEKHS1 | SNV | Missense_Mutation | rs752179427 | c.382N>T | p.Arg128Cys | p.R128C | Q5SXH7 | protein_coding | tolerated(1) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHS1 | SNV | Missense_Mutation | c.1256N>A | p.Arg419Gln | p.R419Q | Q5SXH7 | protein_coding | tolerated_low_confidence(0.62) | benign(0) | TCGA-CA-5797-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PLEKHS1 | SNV | Missense_Mutation | c.70N>C | p.Ser24Pro | p.S24P | Q5SXH7 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PLEKHS1 | SNV | Missense_Mutation | c.515N>T | p.Arg172Ile | p.R172I | Q5SXH7 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
PLEKHS1 | SNV | Missense_Mutation | rs267602368 | c.638G>A | p.Arg213Gln | p.R213Q | Q5SXH7 | protein_coding | tolerated(0.06) | benign(0.372) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLEKHS1 | insertion | Frame_Shift_Ins | rs749797511 | c.1055dupC | p.Arg353ThrfsTer17 | p.R353Tfs*17 | Q5SXH7 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PLEKHS1 | SNV | Missense_Mutation | novel | c.807N>T | p.Glu269Asp | p.E269D | Q5SXH7 | protein_coding | tolerated(0.41) | benign(0.018) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHS1 | SNV | Missense_Mutation | c.420N>T | p.Glu140Asp | p.E140D | Q5SXH7 | protein_coding | deleterious(0.04) | possibly_damaging(0.795) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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