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Gene: PHTF2 |
Gene summary for PHTF2 |
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Gene information | Species | Human | Gene symbol | PHTF2 | Gene ID | 57157 |
Gene name | putative homeodomain transcription factor 2 | |
Gene Alias | PHTF2 | |
Cytomap | 7q11.23-q21.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N3S3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57157 | PHTF2 | LZE4T | Human | Esophagus | ESCC | 6.89e-05 | 2.68e-01 | 0.0811 |
57157 | PHTF2 | LZE7T | Human | Esophagus | ESCC | 3.19e-08 | 4.33e-01 | 0.0667 |
57157 | PHTF2 | LZE20T | Human | Esophagus | ESCC | 3.88e-02 | 9.49e-02 | 0.0662 |
57157 | PHTF2 | LZE24T | Human | Esophagus | ESCC | 6.95e-04 | 1.94e-01 | 0.0596 |
57157 | PHTF2 | LZE21T | Human | Esophagus | ESCC | 3.66e-04 | 1.95e-01 | 0.0655 |
57157 | PHTF2 | LZE6T | Human | Esophagus | ESCC | 3.64e-06 | 2.53e-01 | 0.0845 |
57157 | PHTF2 | P2T-E | Human | Esophagus | ESCC | 1.58e-13 | 2.32e-01 | 0.1177 |
57157 | PHTF2 | P4T-E | Human | Esophagus | ESCC | 1.71e-14 | 3.40e-01 | 0.1323 |
57157 | PHTF2 | P5T-E | Human | Esophagus | ESCC | 1.50e-07 | 1.51e-01 | 0.1327 |
57157 | PHTF2 | P8T-E | Human | Esophagus | ESCC | 1.03e-10 | 7.69e-02 | 0.0889 |
57157 | PHTF2 | P9T-E | Human | Esophagus | ESCC | 8.74e-09 | 2.01e-01 | 0.1131 |
57157 | PHTF2 | P10T-E | Human | Esophagus | ESCC | 8.09e-19 | 2.08e-01 | 0.116 |
57157 | PHTF2 | P11T-E | Human | Esophagus | ESCC | 6.41e-05 | 3.04e-01 | 0.1426 |
57157 | PHTF2 | P12T-E | Human | Esophagus | ESCC | 1.04e-05 | 2.65e-01 | 0.1122 |
57157 | PHTF2 | P15T-E | Human | Esophagus | ESCC | 6.39e-13 | 3.61e-01 | 0.1149 |
57157 | PHTF2 | P16T-E | Human | Esophagus | ESCC | 6.25e-35 | 5.67e-01 | 0.1153 |
57157 | PHTF2 | P17T-E | Human | Esophagus | ESCC | 2.90e-02 | 1.64e-01 | 0.1278 |
57157 | PHTF2 | P20T-E | Human | Esophagus | ESCC | 2.75e-14 | 2.94e-01 | 0.1124 |
57157 | PHTF2 | P21T-E | Human | Esophagus | ESCC | 6.16e-15 | 2.89e-01 | 0.1617 |
57157 | PHTF2 | P22T-E | Human | Esophagus | ESCC | 2.46e-14 | 3.10e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHTF2 | SNV | Missense_Mutation | c.1171N>C | p.Asp391His | p.D391H | Q8N3S3 | protein_coding | deleterious(0.02) | possibly_damaging(0.907) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PHTF2 | SNV | Missense_Mutation | c.1708N>T | p.His570Tyr | p.H570Y | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
PHTF2 | SNV | Missense_Mutation | rs534841738 | c.277C>T | p.Arg93Trp | p.R93W | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PHTF2 | deletion | In_Frame_Del | c.1091_1102delNNNNNNNNNNNN | p.Ser366_Glu369del | p.S366_E369del | Q8N3S3 | protein_coding | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
PHTF2 | SNV | Missense_Mutation | novel | c.575A>G | p.Asn192Ser | p.N192S | Q8N3S3 | protein_coding | tolerated(0.46) | probably_damaging(0.944) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHTF2 | SNV | Missense_Mutation | novel | c.1691G>A | p.Arg564Gln | p.R564Q | Q8N3S3 | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHTF2 | insertion | Frame_Shift_Ins | novel | c.1599_1600insT | p.Leu536PhefsTer10 | p.L536Ffs*10 | Q8N3S3 | protein_coding | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
PHTF2 | SNV | Missense_Mutation | novel | c.73N>A | p.Glu25Lys | p.E25K | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PHTF2 | SNV | Missense_Mutation | c.1715N>A | p.Arg572Gln | p.R572Q | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHTF2 | SNV | Missense_Mutation | rs368376693 | c.1021G>A | p.Ala341Thr | p.A341T | Q8N3S3 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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