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Gene: PCNXL3 |
Gene summary for PCNXL3 |
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Gene information | Species | Human | Gene symbol | PCNXL3 | Gene ID | 399909 |
Gene name | pecanex 3 | |
Gene Alias | PCNXL3 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6A9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399909 | PCNXL3 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.13e-01 | 0.0875 |
399909 | PCNXL3 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.63e-01 | 0.1323 |
399909 | PCNXL3 | P5T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.78e-01 | 0.1327 |
399909 | PCNXL3 | P8T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.71e-01 | 0.0889 |
399909 | PCNXL3 | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.29e-01 | 0.1131 |
399909 | PCNXL3 | P10T-E | Human | Esophagus | ESCC | 4.24e-18 | 2.75e-01 | 0.116 |
399909 | PCNXL3 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 2.66e-01 | 0.1426 |
399909 | PCNXL3 | P12T-E | Human | Esophagus | ESCC | 1.88e-04 | 9.92e-02 | 0.1122 |
399909 | PCNXL3 | P15T-E | Human | Esophagus | ESCC | 1.32e-06 | 1.75e-01 | 0.1149 |
399909 | PCNXL3 | P16T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.27e-01 | 0.1153 |
399909 | PCNXL3 | P17T-E | Human | Esophagus | ESCC | 4.48e-07 | 2.69e-01 | 0.1278 |
399909 | PCNXL3 | P20T-E | Human | Esophagus | ESCC | 4.41e-05 | 1.34e-01 | 0.1124 |
399909 | PCNXL3 | P21T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.88e-01 | 0.1617 |
399909 | PCNXL3 | P23T-E | Human | Esophagus | ESCC | 2.24e-10 | 2.42e-01 | 0.108 |
399909 | PCNXL3 | P26T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.49e-02 | 0.1276 |
399909 | PCNXL3 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.42e-01 | 0.1055 |
399909 | PCNXL3 | P28T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.27e-01 | 0.1149 |
399909 | PCNXL3 | P30T-E | Human | Esophagus | ESCC | 3.11e-08 | 2.68e-01 | 0.137 |
399909 | PCNXL3 | P31T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.23e-01 | 0.1251 |
399909 | PCNXL3 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.96e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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