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Gene: PAGE1 |
Gene summary for PAGE1 |
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Gene information | Species | Human | Gene symbol | PAGE1 | Gene ID | 8712 |
Gene name | PAGE family member 1 | |
Gene Alias | AL5 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | O75459 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8712 | PAGE1 | HCC2 | Human | Liver | HCC | 8.19e-10 | 3.63e+00 | 0.5341 |
8712 | PAGE1 | S014 | Human | Liver | HCC | 2.67e-62 | 2.82e+00 | 0.2254 |
8712 | PAGE1 | S015 | Human | Liver | HCC | 7.49e-39 | 2.43e+00 | 0.2375 |
8712 | PAGE1 | S016 | Human | Liver | HCC | 3.30e-89 | 2.98e+00 | 0.2243 |
8712 | PAGE1 | ATC09 | Human | Thyroid | ATC | 4.52e-12 | 5.38e-01 | 0.2871 |
8712 | PAGE1 | ATC1 | Human | Thyroid | ATC | 8.56e-13 | 6.96e-01 | 0.2878 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAGE1 | SNV | Missense_Mutation | c.10N>G | p.Leu4Val | p.L4V | O75459 | protein_coding | deleterious_low_confidence(0.01) | benign(0.007) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
PAGE1 | SNV | Missense_Mutation | c.4N>A | p.Gly2Ser | p.G2S | O75459 | protein_coding | tolerated_low_confidence(1) | benign(0.015) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
PAGE1 | SNV | Missense_Mutation | c.340N>C | p.Gly114Arg | p.G114R | O75459 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
PAGE1 | SNV | Missense_Mutation | novel | c.161N>T | p.Ala54Val | p.A54V | O75459 | protein_coding | tolerated(1) | probably_damaging(0.955) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAGE1 | SNV | Missense_Mutation | c.24C>G | p.Ile8Met | p.I8M | O75459 | protein_coding | tolerated(0.06) | benign(0.279) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PAGE1 | SNV | Missense_Mutation | c.287N>T | p.Ala96Val | p.A96V | O75459 | protein_coding | tolerated(0.18) | benign(0.152) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAGE1 | SNV | Missense_Mutation | rs782020946 | c.352N>A | p.Gly118Arg | p.G118R | O75459 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
PAGE1 | SNV | Missense_Mutation | rs369503230 | c.29N>T | p.Arg10Leu | p.R10L | O75459 | protein_coding | tolerated(0.09) | possibly_damaging(0.538) | TCGA-A5-A1OG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
PAGE1 | SNV | Missense_Mutation | c.152N>T | p.Ala51Val | p.A51V | O75459 | protein_coding | deleterious(0.04) | possibly_damaging(0.487) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PAGE1 | SNV | Missense_Mutation | c.287N>T | p.Ala96Val | p.A96V | O75459 | protein_coding | tolerated(0.18) | benign(0.152) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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