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Gene: NPB |
Gene summary for NPB |
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Gene information | Species | Human | Gene symbol | NPB | Gene ID | 256933 |
Gene name | neuropeptide B | |
Gene Alias | L7 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8NG41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256933 | NPB | LZE22T | Human | Esophagus | ESCC | 1.48e-05 | 5.35e-01 | 0.068 |
256933 | NPB | P2T-E | Human | Esophagus | ESCC | 1.85e-55 | 9.51e-01 | 0.1177 |
256933 | NPB | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.93e-01 | 0.1323 |
256933 | NPB | P9T-E | Human | Esophagus | ESCC | 8.38e-03 | 1.25e-01 | 0.1131 |
256933 | NPB | P10T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.64e-02 | 0.116 |
256933 | NPB | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 3.18e-01 | 0.1426 |
256933 | NPB | P12T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.13e-01 | 0.1122 |
256933 | NPB | P16T-E | Human | Esophagus | ESCC | 1.79e-70 | 1.39e+00 | 0.1153 |
256933 | NPB | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.03e-01 | 0.1278 |
256933 | NPB | P20T-E | Human | Esophagus | ESCC | 1.63e-40 | 8.64e-01 | 0.1124 |
256933 | NPB | P21T-E | Human | Esophagus | ESCC | 5.88e-35 | 7.18e-01 | 0.1617 |
256933 | NPB | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.78e-01 | 0.1236 |
256933 | NPB | P23T-E | Human | Esophagus | ESCC | 3.36e-03 | 1.30e-01 | 0.108 |
256933 | NPB | P24T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.35e-01 | 0.1287 |
256933 | NPB | P26T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.26e-01 | 0.1276 |
256933 | NPB | P27T-E | Human | Esophagus | ESCC | 3.97e-04 | 2.05e-01 | 0.1055 |
256933 | NPB | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 2.25e-01 | 0.137 |
256933 | NPB | P31T-E | Human | Esophagus | ESCC | 1.41e-52 | 9.23e-01 | 0.1251 |
256933 | NPB | P32T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.65e-01 | 0.1666 |
256933 | NPB | P37T-E | Human | Esophagus | ESCC | 3.50e-19 | 4.33e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPB | SNV | Missense_Mutation | rs778717259 | c.371N>T | p.Ala124Val | p.A124V | Q8NG41 | protein_coding | deleterious(0.03) | benign(0.215) | TCGA-AY-A8YK-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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