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Gene: NFIX |
Gene summary for NFIX |
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Gene information | Species | Human | Gene symbol | NFIX | Gene ID | 4784 |
Gene name | nuclear factor I X | |
Gene Alias | CTF | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B4DHW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4784 | NFIX | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.79e-02 | 1.39e-01 | 0.0155 |
4784 | NFIX | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.95e-02 | 2.57e-01 | -0.0811 |
4784 | NFIX | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.13e-03 | 4.49e-01 | 0.0338 |
4784 | NFIX | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.93e-11 | 7.39e-01 | 0.0674 |
4784 | NFIX | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.40e-04 | 5.52e-01 | 0.0588 |
4784 | NFIX | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.04e-09 | 7.38e-01 | 0.281 |
4784 | NFIX | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.09e-13 | 7.79e-01 | 0.3859 |
4784 | NFIX | A015-C-203 | Human | Colorectum | FAP | 8.92e-11 | -2.05e-02 | -0.1294 |
4784 | NFIX | A001-C-108 | Human | Colorectum | FAP | 6.40e-07 | 1.40e-01 | -0.0272 |
4784 | NFIX | A002-C-205 | Human | Colorectum | FAP | 6.21e-04 | -7.71e-02 | -0.1236 |
4784 | NFIX | A015-C-106 | Human | Colorectum | FAP | 1.61e-05 | 2.00e-01 | -0.0511 |
4784 | NFIX | A002-C-114 | Human | Colorectum | FAP | 1.89e-02 | -8.35e-02 | -0.1561 |
4784 | NFIX | A015-C-104 | Human | Colorectum | FAP | 8.13e-14 | 1.06e-01 | -0.1899 |
4784 | NFIX | A001-C-014 | Human | Colorectum | FAP | 2.35e-03 | 8.15e-02 | 0.0135 |
4784 | NFIX | A002-C-016 | Human | Colorectum | FAP | 5.45e-06 | -2.01e-02 | 0.0521 |
4784 | NFIX | A001-C-203 | Human | Colorectum | FAP | 2.04e-04 | 8.55e-02 | -0.0481 |
4784 | NFIX | A002-C-116 | Human | Colorectum | FAP | 1.06e-14 | -1.32e-01 | -0.0452 |
4784 | NFIX | A018-E-020 | Human | Colorectum | FAP | 5.07e-03 | -1.05e-01 | -0.2034 |
4784 | NFIX | F034 | Human | Colorectum | FAP | 1.74e-09 | 1.04e-01 | -0.0665 |
4784 | NFIX | F072B | Human | Colorectum | FAP | 1.14e-02 | -6.00e-02 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062605 | Skin | AK | DNA replication | 40/1910 | 260/18723 | 5.49e-03 | 3.03e-02 | 40 |
GO:000626012 | Skin | cSCC | DNA replication | 106/4864 | 260/18723 | 1.18e-07 | 2.77e-06 | 106 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFIX | insertion | Nonsense_Mutation | novel | c.458_459insAGTGAGGGAGAGAGAGAGAGAATAGGTGTGT | p.Pro154ValfsTer8 | p.P154Vfs*8 | Q14938 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
NFIX | SNV | Missense_Mutation | c.791G>A | p.Arg264Gln | p.R264Q | Q14938 | protein_coding | tolerated(0.06) | benign(0.232) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | c.889N>A | p.Gly297Arg | p.G297R | Q14938 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-EF-5830-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | novel | c.310G>A | p.Val104Met | p.V104M | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.184G>T | p.Gly62Cys | p.G62C | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | c.830N>A | p.Arg277His | p.R277H | Q14938 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | rs771724729 | c.239G>A | p.Arg80His | p.R80H | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.959N>T | p.Pro320Leu | p.P320L | Q14938 | protein_coding | tolerated(0.85) | benign(0.009) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.671T>C | p.Val224Ala | p.V224A | Q14938 | protein_coding | tolerated(0.08) | probably_damaging(0.991) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.305N>T | p.Cys102Phe | p.C102F | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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