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Gene: NEK9 |
Gene summary for NEK9 |
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Gene information | Species | Human | Gene symbol | NEK9 | Gene ID | 91754 |
Gene name | NIMA related kinase 9 | |
Gene Alias | APUG | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8TD19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91754 | NEK9 | LZE2T | Human | Esophagus | ESCC | 8.70e-08 | 5.62e-01 | 0.082 |
91754 | NEK9 | LZE4T | Human | Esophagus | ESCC | 7.46e-19 | 4.12e-01 | 0.0811 |
91754 | NEK9 | LZE7T | Human | Esophagus | ESCC | 4.00e-03 | 2.89e-01 | 0.0667 |
91754 | NEK9 | LZE8T | Human | Esophagus | ESCC | 1.95e-02 | 1.66e-01 | 0.067 |
91754 | NEK9 | LZE20T | Human | Esophagus | ESCC | 8.47e-03 | 1.52e-01 | 0.0662 |
91754 | NEK9 | LZE24T | Human | Esophagus | ESCC | 9.44e-15 | 3.64e-01 | 0.0596 |
91754 | NEK9 | LZE6T | Human | Esophagus | ESCC | 3.13e-02 | 1.10e-01 | 0.0845 |
91754 | NEK9 | P1T-E | Human | Esophagus | ESCC | 6.93e-05 | 2.14e-01 | 0.0875 |
91754 | NEK9 | P2T-E | Human | Esophagus | ESCC | 2.05e-20 | 3.42e-01 | 0.1177 |
91754 | NEK9 | P4T-E | Human | Esophagus | ESCC | 1.31e-18 | 4.57e-01 | 0.1323 |
91754 | NEK9 | P5T-E | Human | Esophagus | ESCC | 1.47e-06 | 7.48e-02 | 0.1327 |
91754 | NEK9 | P8T-E | Human | Esophagus | ESCC | 3.90e-25 | 3.79e-01 | 0.0889 |
91754 | NEK9 | P9T-E | Human | Esophagus | ESCC | 6.60e-17 | 2.08e-01 | 0.1131 |
91754 | NEK9 | P10T-E | Human | Esophagus | ESCC | 2.44e-34 | 4.89e-01 | 0.116 |
91754 | NEK9 | P11T-E | Human | Esophagus | ESCC | 1.10e-09 | 3.95e-01 | 0.1426 |
91754 | NEK9 | P12T-E | Human | Esophagus | ESCC | 4.27e-27 | 4.53e-01 | 0.1122 |
91754 | NEK9 | P15T-E | Human | Esophagus | ESCC | 3.51e-30 | 6.76e-01 | 0.1149 |
91754 | NEK9 | P16T-E | Human | Esophagus | ESCC | 3.44e-16 | 3.13e-01 | 0.1153 |
91754 | NEK9 | P17T-E | Human | Esophagus | ESCC | 4.66e-03 | 2.08e-01 | 0.1278 |
91754 | NEK9 | P19T-E | Human | Esophagus | ESCC | 1.01e-02 | 2.05e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEK9 | SNV | Missense_Mutation | novel | c.1006N>C | p.Glu336Gln | p.E336Q | Q8TD19 | protein_coding | tolerated(0.23) | benign(0.073) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NEK9 | SNV | Missense_Mutation | rs768731171 | c.2928N>C | p.Arg976Ser | p.R976S | Q8TD19 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.879) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEK9 | SNV | Missense_Mutation | c.829T>C | p.Tyr277His | p.Y277H | Q8TD19 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEK9 | SNV | Missense_Mutation | c.2831N>T | p.Ser944Phe | p.S944F | Q8TD19 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.564) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NEK9 | SNV | Missense_Mutation | rs768731171 | c.2928N>C | p.Arg976Ser | p.R976S | Q8TD19 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.879) | TCGA-BH-A1F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NEK9 | SNV | Missense_Mutation | rs768731171 | c.2928A>C | p.Arg976Ser | p.R976S | Q8TD19 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.879) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
NEK9 | SNV | Missense_Mutation | rs768731171 | c.2928N>C | p.Arg976Ser | p.R976S | Q8TD19 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.879) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
NEK9 | SNV | Missense_Mutation | rs768731171 | c.2928A>C | p.Arg976Ser | p.R976S | Q8TD19 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.879) | TCGA-D8-A1X7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
NEK9 | SNV | Missense_Mutation | novel | c.2353N>C | p.Asp785His | p.D785H | Q8TD19 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.501) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NEK9 | insertion | In_Frame_Ins | novel | c.2271_2272insTTGGCTGAGCATTTCACTGAAGTT | p.Gly757_Gly758insLeuAlaGluHisPheThrGluVal | p.G757_G758insLAEHFTEV | Q8TD19 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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