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Gene: NAIF1 |
Gene summary for NAIF1 |
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Gene information | Species | Human | Gene symbol | NAIF1 | Gene ID | 203245 |
Gene name | nuclear apoptosis inducing factor 1 | |
Gene Alias | C9orf90 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | A0A024R887 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203245 | NAIF1 | HCC1 | Human | Liver | HCC | 1.11e-10 | 1.37e+00 | 0.5336 |
203245 | NAIF1 | HCC2 | Human | Liver | HCC | 2.33e-32 | 1.92e+00 | 0.5341 |
203245 | NAIF1 | HCC5 | Human | Liver | HCC | 3.80e-24 | 1.94e+00 | 0.4932 |
203245 | NAIF1 | S014 | Human | Liver | HCC | 1.88e-02 | 1.49e-01 | 0.2254 |
203245 | NAIF1 | S015 | Human | Liver | HCC | 7.00e-09 | 2.69e-01 | 0.2375 |
203245 | NAIF1 | S016 | Human | Liver | HCC | 5.65e-08 | 2.44e-01 | 0.2243 |
203245 | NAIF1 | S028 | Human | Liver | HCC | 8.09e-05 | 1.93e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000700612 | Liver | HCC | mitochondrial membrane organization | 80/7958 | 116/18723 | 7.09e-09 | 1.81e-07 | 80 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:000863712 | Liver | HCC | apoptotic mitochondrial changes | 70/7958 | 107/18723 | 1.39e-06 | 2.01e-05 | 70 |
GO:009055912 | Liver | HCC | regulation of membrane permeability | 47/7958 | 78/18723 | 1.17e-03 | 6.54e-03 | 47 |
GO:004690212 | Liver | HCC | regulation of mitochondrial membrane permeability | 39/7958 | 63/18723 | 1.47e-03 | 7.80e-03 | 39 |
GO:00459263 | Liver | HCC | negative regulation of growth | 129/7958 | 249/18723 | 1.81e-03 | 9.37e-03 | 129 |
GO:0030308 | Liver | HCC | negative regulation of cell growth | 98/7958 | 188/18723 | 4.74e-03 | 2.02e-02 | 98 |
GO:190210811 | Liver | HCC | regulation of mitochondrial membrane permeability involved in apoptotic process | 28/7958 | 45/18723 | 5.99e-03 | 2.45e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAIF1 | SNV | Missense_Mutation | c.967N>A | p.Asp323Asn | p.D323N | Q69YI7 | protein_coding | deleterious_low_confidence(0) | benign(0.435) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NAIF1 | SNV | Missense_Mutation | novel | c.628G>C | p.Asp210His | p.D210H | Q69YI7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.276) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
NAIF1 | SNV | Missense_Mutation | c.132N>C | p.Lys44Asn | p.K44N | Q69YI7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
NAIF1 | SNV | Missense_Mutation | rs144611939 | c.304N>A | p.Asp102Asn | p.D102N | Q69YI7 | protein_coding | tolerated_low_confidence(0.1) | benign(0.01) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAIF1 | insertion | Nonsense_Mutation | novel | c.772_773insCTCTTTAATAAACGCTTAGG | p.Arg258ProfsTer3 | p.R258Pfs*3 | Q69YI7 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
NAIF1 | SNV | Missense_Mutation | rs376436007 | c.809G>A | p.Arg270His | p.R270H | Q69YI7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.98) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAIF1 | SNV | Missense_Mutation | c.66G>T | p.Glu22Asp | p.E22D | Q69YI7 | protein_coding | tolerated(0.18) | probably_damaging(0.983) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NAIF1 | SNV | Missense_Mutation | c.890N>A | p.Arg297His | p.R297H | Q69YI7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.98) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NAIF1 | SNV | Missense_Mutation | novel | c.677N>T | p.Ser226Phe | p.S226F | Q69YI7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
NAIF1 | SNV | Missense_Mutation | c.184C>T | p.Arg62Cys | p.R62C | Q69YI7 | protein_coding | deleterious(0.04) | possibly_damaging(0.679) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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