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Gene: MTRNR2L12 |
Gene summary for MTRNR2L12 |
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Gene information | Species | Human | Gene symbol | MTRNR2L12 | Gene ID | 100463498 |
Gene name | MT-RNR2 like 12 | |
Gene Alias | HN12 | |
Cytomap | 3q11.2 | |
Gene Type | pseudo | GO ID | GO:0006915 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100463498 | MTRNR2L12 | GSM4909281 | Human | Breast | IDC | 1.44e-11 | -5.37e-01 | 0.21 |
100463498 | MTRNR2L12 | GSM4909282 | Human | Breast | IDC | 5.49e-26 | -7.35e-01 | -0.0288 |
100463498 | MTRNR2L12 | GSM4909285 | Human | Breast | IDC | 2.84e-24 | -7.41e-01 | 0.21 |
100463498 | MTRNR2L12 | GSM4909286 | Human | Breast | IDC | 1.13e-13 | -2.96e-01 | 0.1081 |
100463498 | MTRNR2L12 | GSM4909290 | Human | Breast | IDC | 3.10e-14 | -7.16e-01 | 0.2096 |
100463498 | MTRNR2L12 | GSM4909293 | Human | Breast | IDC | 3.72e-25 | 6.37e-01 | 0.1581 |
100463498 | MTRNR2L12 | GSM4909296 | Human | Breast | IDC | 2.17e-08 | -5.20e-01 | 0.1524 |
100463498 | MTRNR2L12 | GSM4909298 | Human | Breast | IDC | 1.41e-11 | -4.38e-01 | 0.1551 |
100463498 | MTRNR2L12 | GSM4909299 | Human | Breast | IDC | 6.45e-08 | -3.49e-01 | 0.035 |
100463498 | MTRNR2L12 | GSM4909301 | Human | Breast | IDC | 1.76e-32 | -7.98e-01 | 0.1577 |
100463498 | MTRNR2L12 | GSM4909302 | Human | Breast | IDC | 5.25e-13 | -6.12e-01 | 0.1545 |
100463498 | MTRNR2L12 | GSM4909304 | Human | Breast | IDC | 9.51e-08 | -1.27e-01 | 0.1636 |
100463498 | MTRNR2L12 | GSM4909306 | Human | Breast | IDC | 2.65e-04 | -3.58e-01 | 0.1564 |
100463498 | MTRNR2L12 | GSM4909307 | Human | Breast | IDC | 6.73e-17 | -6.77e-01 | 0.1569 |
100463498 | MTRNR2L12 | GSM4909308 | Human | Breast | IDC | 2.75e-28 | -8.27e-01 | 0.158 |
100463498 | MTRNR2L12 | GSM4909309 | Human | Breast | IDC | 1.11e-07 | -5.41e-01 | 0.0483 |
100463498 | MTRNR2L12 | GSM4909311 | Human | Breast | IDC | 5.80e-14 | -4.56e-01 | 0.1534 |
100463498 | MTRNR2L12 | GSM4909312 | Human | Breast | IDC | 4.29e-10 | -5.58e-01 | 0.1552 |
100463498 | MTRNR2L12 | GSM4909313 | Human | Breast | IDC | 2.64e-15 | -6.81e-01 | 0.0391 |
100463498 | MTRNR2L12 | GSM4909315 | Human | Breast | IDC | 1.34e-02 | -3.43e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
GO:1900117 | Liver | HCC | regulation of execution phase of apoptosis | 19/7958 | 29/18723 | 1.05e-02 | 3.89e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTRNR2L12 | SNV | Missense_Mutation | c.11N>A | p.Arg4Gln | p.R4Q | P0DMP1 | protein_coding | tolerated_low_confidence(0.27) | benign(0.412) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTRNR2L12 | SNV | Missense_Mutation | c.31C>A | p.Leu11Ile | p.L11I | P0DMP1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.578) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
MTRNR2L12 | SNV | Missense_Mutation | c.11G>A | p.Arg4Gln | p.R4Q | P0DMP1 | protein_coding | tolerated_low_confidence(0.27) | benign(0.412) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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