![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MRPL37 |
Gene summary for MRPL37 |
![]() |
Gene information | Species | Human | Gene symbol | MRPL37 | Gene ID | 51253 |
Gene name | mitochondrial ribosomal protein L37 | |
Gene Alias | L2mt | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | S4R369 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51253 | MRPL37 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.68e-10 | 4.00e-01 | 0.0155 |
51253 | MRPL37 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.23e-06 | 4.93e-01 | -0.1808 |
51253 | MRPL37 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.04e-02 | 4.49e-01 | 0.0216 |
51253 | MRPL37 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.46e-11 | 6.19e-01 | -0.0811 |
51253 | MRPL37 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.73e-08 | 4.79e-01 | -0.1088 |
51253 | MRPL37 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-13 | 5.03e-01 | -0.1954 |
51253 | MRPL37 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.07e-04 | 7.90e-01 | -0.2602 |
51253 | MRPL37 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.06e-04 | 4.75e-01 | -0.1207 |
51253 | MRPL37 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.92e-24 | 7.45e-01 | -0.1464 |
51253 | MRPL37 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.45e-07 | 3.09e-01 | -0.1001 |
51253 | MRPL37 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.28e-21 | 7.99e-01 | -0.059 |
51253 | MRPL37 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.65e-03 | 5.89e-01 | -0.1706 |
51253 | MRPL37 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.25e-04 | 4.43e-01 | -0.2061 |
51253 | MRPL37 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.71e-04 | 4.96e-01 | -0.1462 |
51253 | MRPL37 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.40e-09 | 6.05e-01 | -0.0842 |
51253 | MRPL37 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.72e-07 | 5.38e-01 | -0.0179 |
51253 | MRPL37 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.16e-16 | 6.08e-01 | 0.096 |
51253 | MRPL37 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.04e-04 | 4.71e-01 | 0.0528 |
51253 | MRPL37 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.59e-06 | 6.54e-01 | 0.0131 |
51253 | MRPL37 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.54e-06 | 6.92e-01 | 0.0171 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL37 | SNV | Missense_Mutation | rs768836635 | c.110N>T | p.Ser37Phe | p.S37F | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.956) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MRPL37 | insertion | Nonsense_Mutation | novel | c.961_962insGTCATGGCTGAAAAGAACAAGTACTAAACTTTGATTCTCAGCA | p.Ala321GlyfsTer4 | p.A321Gfs*4 | protein_coding | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
MRPL37 | insertion | Nonsense_Mutation | novel | c.1164_1165insTGTAAAGGGAAGAACTAGAAG | p.Cys388_Leu389insCysLysGlyLysAsnTerLys | p.C388_L389insCKGKN*K | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MRPL37 | SNV | Missense_Mutation | novel | c.832G>A | p.Gly278Arg | p.G278R | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MRPL37 | SNV | Missense_Mutation | novel | c.1379G>A | p.Arg460His | p.R460H | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MRPL37 | SNV | Missense_Mutation | rs369065705 | c.1033G>A | p.Val345Met | p.V345M | protein_coding | deleterious(0.05) | benign(0.115) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MRPL37 | SNV | Missense_Mutation | c.349G>A | p.Val117Ile | p.V117I | protein_coding | tolerated(0.11) | benign(0.373) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MRPL37 | SNV | Missense_Mutation | rs753105572 | c.1040C>T | p.Thr347Met | p.T347M | protein_coding | deleterious(0.05) | probably_damaging(0.959) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
MRPL37 | SNV | Missense_Mutation | novel | c.892N>C | p.Asn298His | p.N298H | protein_coding | deleterious(0) | benign(0.046) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD | |
MRPL37 | insertion | Frame_Shift_Ins | novel | c.1181dupA | p.Arg395GlufsTer7 | p.R395Efs*7 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |