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Gene: MROH1 |
Gene summary for MROH1 |
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Gene information | Species | Human | Gene symbol | MROH1 | Gene ID | 727957 |
Gene name | maestro heat like repeat family member 1 | |
Gene Alias | HEATR7A | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | B4DIR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
727957 | MROH1 | LZE4T | Human | Esophagus | ESCC | 6.84e-04 | 1.38e-01 | 0.0811 |
727957 | MROH1 | LZE7T | Human | Esophagus | ESCC | 5.88e-06 | 2.56e-01 | 0.0667 |
727957 | MROH1 | LZE8T | Human | Esophagus | ESCC | 9.46e-06 | 1.33e-01 | 0.067 |
727957 | MROH1 | LZE20T | Human | Esophagus | ESCC | 6.78e-08 | 2.26e-01 | 0.0662 |
727957 | MROH1 | LZE24T | Human | Esophagus | ESCC | 3.80e-11 | 1.81e-01 | 0.0596 |
727957 | MROH1 | P1T-E | Human | Esophagus | ESCC | 1.55e-09 | 3.53e-01 | 0.0875 |
727957 | MROH1 | P2T-E | Human | Esophagus | ESCC | 9.57e-14 | 1.33e-01 | 0.1177 |
727957 | MROH1 | P4T-E | Human | Esophagus | ESCC | 6.99e-08 | 1.18e-01 | 0.1323 |
727957 | MROH1 | P5T-E | Human | Esophagus | ESCC | 3.41e-10 | 1.86e-01 | 0.1327 |
727957 | MROH1 | P8T-E | Human | Esophagus | ESCC | 2.30e-09 | 1.12e-01 | 0.0889 |
727957 | MROH1 | P9T-E | Human | Esophagus | ESCC | 3.35e-05 | 1.37e-01 | 0.1131 |
727957 | MROH1 | P10T-E | Human | Esophagus | ESCC | 9.41e-12 | 1.49e-01 | 0.116 |
727957 | MROH1 | P11T-E | Human | Esophagus | ESCC | 1.55e-03 | 1.77e-01 | 0.1426 |
727957 | MROH1 | P12T-E | Human | Esophagus | ESCC | 5.62e-11 | 1.76e-01 | 0.1122 |
727957 | MROH1 | P15T-E | Human | Esophagus | ESCC | 1.30e-11 | 2.34e-01 | 0.1149 |
727957 | MROH1 | P16T-E | Human | Esophagus | ESCC | 6.60e-17 | 2.33e-01 | 0.1153 |
727957 | MROH1 | P17T-E | Human | Esophagus | ESCC | 3.82e-04 | 2.24e-01 | 0.1278 |
727957 | MROH1 | P20T-E | Human | Esophagus | ESCC | 1.74e-04 | 1.08e-01 | 0.1124 |
727957 | MROH1 | P21T-E | Human | Esophagus | ESCC | 1.50e-19 | 4.42e-01 | 0.1617 |
727957 | MROH1 | P22T-E | Human | Esophagus | ESCC | 3.12e-17 | 1.04e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MROH1 | SNV | Missense_Mutation | novel | c.4397N>A | p.Arg1466Gln | p.R1466Q | Q8NDA8 | protein_coding | deleterious(0) | possibly_damaging(0.733) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MROH1 | SNV | Missense_Mutation | novel | c.3860A>G | p.Asp1287Gly | p.D1287G | Q8NDA8 | protein_coding | tolerated(0.14) | benign(0.05) | TCGA-B6-A0I1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MROH1 | SNV | Missense_Mutation | rs189264844 | c.814N>A | p.Ala272Thr | p.A272T | Q8NDA8 | protein_coding | tolerated(0.08) | benign(0.091) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MROH1 | SNV | Missense_Mutation | novel | c.2692N>T | p.His898Tyr | p.H898Y | Q8NDA8 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-D8-A1JF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MROH1 | SNV | Missense_Mutation | novel | c.4495C>A | p.Leu1499Met | p.L1499M | Q8NDA8 | protein_coding | tolerated(0.07) | probably_damaging(0.96) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MROH1 | SNV | Missense_Mutation | rs755630252 | c.119N>T | p.Pro40Leu | p.P40L | Q8NDA8 | protein_coding | deleterious(0) | benign(0.097) | TCGA-E9-A54Y-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MROH1 | SNV | Missense_Mutation | novel | c.3740A>T | p.Glu1247Val | p.E1247V | Q8NDA8 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MROH1 | SNV | Missense_Mutation | novel | c.3200A>C | p.Lys1067Thr | p.K1067T | Q8NDA8 | protein_coding | tolerated(0.38) | benign(0.046) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MROH1 | deletion | Frame_Shift_Del | novel | c.1393delN | p.Ile465SerfsTer16 | p.I465Sfs*16 | Q8NDA8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MROH1 | deletion | Frame_Shift_Del | novel | c.2248delC | p.Arg750GlyfsTer11 | p.R750Gfs*11 | Q8NDA8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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