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Gene: MRE11A |
Gene summary for MRE11A |
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Gene information | Species | Human | Gene symbol | MRE11A | Gene ID | 4361 |
Gene name | MRE11 homolog, double strand break repair nuclease | |
Gene Alias | ATLD | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | F8W7U8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4361 | MRE11A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.15e-20 | 3.38e-01 | 0.294 |
4361 | MRE11A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.40e-05 | 5.85e-01 | 0.3487 |
4361 | MRE11A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.03e-08 | 2.57e-01 | 0.281 |
4361 | MRE11A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.61e-27 | 5.03e-01 | 0.3859 |
4361 | MRE11A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.26e-07 | 3.09e-01 | 0.2585 |
4361 | MRE11A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.36e-06 | 1.58e-01 | 0.3005 |
4361 | MRE11A | P2T-E | Human | Esophagus | ESCC | 3.21e-12 | 2.44e-01 | 0.1177 |
4361 | MRE11A | P4T-E | Human | Esophagus | ESCC | 9.21e-16 | 5.13e-01 | 0.1323 |
4361 | MRE11A | P5T-E | Human | Esophagus | ESCC | 6.69e-06 | 2.04e-01 | 0.1327 |
4361 | MRE11A | P8T-E | Human | Esophagus | ESCC | 9.74e-20 | 4.53e-01 | 0.0889 |
4361 | MRE11A | P9T-E | Human | Esophagus | ESCC | 1.28e-21 | 1.75e-01 | 0.1131 |
4361 | MRE11A | P10T-E | Human | Esophagus | ESCC | 2.08e-17 | 3.07e-01 | 0.116 |
4361 | MRE11A | P11T-E | Human | Esophagus | ESCC | 3.94e-09 | 2.63e-01 | 0.1426 |
4361 | MRE11A | P12T-E | Human | Esophagus | ESCC | 4.03e-21 | 3.40e-01 | 0.1122 |
4361 | MRE11A | P15T-E | Human | Esophagus | ESCC | 7.83e-08 | 1.25e-01 | 0.1149 |
4361 | MRE11A | P16T-E | Human | Esophagus | ESCC | 5.15e-18 | 2.60e-01 | 0.1153 |
4361 | MRE11A | P20T-E | Human | Esophagus | ESCC | 2.09e-14 | 1.30e-01 | 0.1124 |
4361 | MRE11A | P21T-E | Human | Esophagus | ESCC | 5.07e-19 | 3.59e-01 | 0.1617 |
4361 | MRE11A | P22T-E | Human | Esophagus | ESCC | 4.74e-11 | 1.65e-01 | 0.1236 |
4361 | MRE11A | P23T-E | Human | Esophagus | ESCC | 4.65e-11 | 2.51e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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