GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:004563710 | Cervix | CC | regulation of myeloid cell differentiation | 48/2311 | 210/18723 | 1.49e-05 | 2.93e-04 | 48 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:0033002 | Cervix | CC | muscle cell proliferation | 49/2311 | 248/18723 | 5.43e-04 | 5.24e-03 | 49 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:0014855 | Cervix | CC | striated muscle cell proliferation | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
GO:0045665 | Cervix | CC | negative regulation of neuron differentiation | 16/2311 | 69/18723 | 8.75e-03 | 4.48e-02 | 16 |
GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
GO:003009925 | Cervix | N_HPV | myeloid cell differentiation | 33/534 | 381/18723 | 1.61e-08 | 2.52e-06 | 33 |
GO:004563723 | Cervix | N_HPV | regulation of myeloid cell differentiation | 21/534 | 210/18723 | 6.68e-07 | 4.00e-05 | 21 |
GO:190370623 | Cervix | N_HPV | regulation of hemopoiesis | 29/534 | 367/18723 | 8.22e-07 | 4.74e-05 | 29 |
GO:00615151 | Cervix | N_HPV | myeloid cell development | 10/534 | 71/18723 | 3.17e-05 | 8.16e-04 | 10 |
GO:00987511 | Cervix | N_HPV | bone cell development | 7/534 | 34/18723 | 4.07e-05 | 9.70e-04 | 7 |
GO:00603482 | Cervix | N_HPV | bone development | 15/534 | 205/18723 | 8.27e-04 | 1.02e-02 | 15 |
GO:0030219 | Cervix | N_HPV | megakaryocyte differentiation | 6/534 | 57/18723 | 5.54e-03 | 3.94e-02 | 6 |
GO:006053722 | Cervix | N_HPV | muscle tissue development | 21/534 | 403/18723 | 6.10e-03 | 4.21e-02 | 21 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MEIS1 | BAS | Cervix | CC | MEIS1-AS2,LINC01798,PECAM1, etc. | 8.26e-04 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
MEIS1 | COL | Cervix | CC | MEIS1-AS2,LINC01798,PECAM1, etc. | 5.12e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
MEIS1 | MES | Cervix | N_HPV | MEIS1-AS2,LINC01798,PECAM1, etc. | 4.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_N_HPV/regulons_activity_in_dotplot.png) |
MEIS1 | CT | Colorectum | SER | SPIB,ADCY5,NBPF19, etc. | 6.67e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_SER/regulons_activity_in_dotplot.png) |
MEIS1 | PERI | Lung | IAC | NCALD,SETBP1,PRICKLE2, etc. | 4.60e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
MEIS1 | STM | Pancreas | Healthy | AC091607.2,NLK,TDRD3, etc. | 5.19e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
MEIS1 | EE | Stomach | CAG | MEIS2,GAST,ERO1B, etc. | 1.67e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CAG/regulons_activity_in_dotplot.png) |
MEIS1 | EE | Stomach | CSG | MEIS2,GAST,ERO1B, etc. | 2.47e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_CSG/regulons_activity_in_dotplot.png) |
MEIS1 | A.X | Stomach | GC | MEIS2,GAST,ERO1B, etc. | 7.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_GC/regulons_activity_in_dotplot.png) |
MEIS1 | EE | Stomach | SIM | MEIS2,GAST,ERO1B, etc. | 1.13e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Stomach/Str/TF_SIM/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEIS1 | SNV | Missense_Mutation | novel | c.1051N>A | p.Asp351Asn | p.D351N | O00470 | protein_coding | deleterious(0) | benign(0.057) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MEIS1 | SNV | Missense_Mutation | | c.826N>T | p.Arg276Cys | p.R276C | O00470 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MEIS1 | SNV | Missense_Mutation | novel | c.220N>T | p.Asp74Tyr | p.D74Y | O00470 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEIS1 | SNV | Missense_Mutation | novel | c.883N>G | p.Leu295Val | p.L295V | O00470 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
MEIS1 | deletion | Frame_Shift_Del | | c.921_927delGTTGGCA | p.Gln307HisfsTer11 | p.Q307Hfs*11 | O00470 | protein_coding | | | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEIS1 | insertion | Frame_Shift_Ins | novel | c.522_523insTGTATCTTTGC | p.Ser175CysfsTer7 | p.S175Cfs*7 | O00470 | protein_coding | | | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEIS1 | insertion | Nonsense_Mutation | novel | c.524_525insATGATTCAAGCCATACAAGTATTAAGGTTTCAT | p.Ser175delinsArgTerPheLysProTyrLysTyrTerGlyPheIle | p.S175delinsR*FKPYKY*GFI | O00470 | protein_coding | | | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEIS1 | SNV | Missense_Mutation | | c.140N>G | p.Ser47Trp | p.S47W | O00470 | protein_coding | tolerated(0.12) | possibly_damaging(0.708) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MEIS1 | SNV | Missense_Mutation | rs780370917 | c.178N>A | p.Ala60Thr | p.A60T | O00470 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MEIS1 | SNV | Missense_Mutation | | c.65C>T | p.Thr22Met | p.T22M | O00470 | protein_coding | deleterious(0.02) | possibly_damaging(0.508) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |