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Gene: MED23 |
Gene summary for MED23 |
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Gene information | Species | Human | Gene symbol | MED23 | Gene ID | 9439 |
Gene name | mediator complex subunit 23 | |
Gene Alias | ARC130 | |
Cytomap | 6q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05DL5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9439 | MED23 | HCC1_Meng | Human | Liver | HCC | 5.55e-09 | -3.35e-02 | 0.0246 |
9439 | MED23 | HCC2_Meng | Human | Liver | HCC | 1.68e-18 | 7.35e-02 | 0.0107 |
9439 | MED23 | HCC1 | Human | Liver | HCC | 1.19e-03 | 3.11e+00 | 0.5336 |
9439 | MED23 | HCC2 | Human | Liver | HCC | 2.38e-05 | 1.33e+00 | 0.5341 |
9439 | MED23 | S015 | Human | Liver | HCC | 1.34e-03 | 2.93e-01 | 0.2375 |
9439 | MED23 | S016 | Human | Liver | HCC | 2.07e-03 | 1.92e-01 | 0.2243 |
9439 | MED23 | S029 | Human | Liver | HCC | 9.08e-05 | 2.27e-01 | 0.2581 |
9439 | MED23 | HTA12-23-1 | Human | Pancreas | PDAC | 1.54e-02 | 5.19e-01 | 0.3405 |
9439 | MED23 | HTA12-26-1 | Human | Pancreas | PDAC | 1.29e-09 | 5.65e-01 | 0.3728 |
9439 | MED23 | HTA12-29-1 | Human | Pancreas | PDAC | 4.21e-19 | 4.15e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063671 | Liver | HCC | transcription initiation from RNA polymerase II promoter | 52/7958 | 77/18723 | 7.87e-06 | 9.27e-05 | 52 |
GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED23 | SNV | Missense_Mutation | rs773757521 | c.3058N>A | p.Ala1020Thr | p.A1020T | Q9ULK4 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD |
MED23 | SNV | Missense_Mutation | c.1597G>T | p.Val533Phe | p.V533F | Q9ULK4 | protein_coding | tolerated(0.08) | probably_damaging(0.987) | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MED23 | SNV | Missense_Mutation | c.1718A>G | p.Tyr573Cys | p.Y573C | Q9ULK4 | protein_coding | deleterious(0.05) | possibly_damaging(0.663) | TCGA-A2-A3KC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MED23 | SNV | Missense_Mutation | c.3761C>T | p.Pro1254Leu | p.P1254L | Q9ULK4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
MED23 | SNV | Missense_Mutation | c.836C>G | p.Ser279Cys | p.S279C | Q9ULK4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD | |
MED23 | SNV | Missense_Mutation | c.1718A>G | p.Tyr573Cys | p.Y573C | Q9ULK4 | protein_coding | deleterious(0.05) | possibly_damaging(0.663) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MED23 | SNV | Missense_Mutation | c.1718A>G | p.Tyr573Cys | p.Y573C | Q9ULK4 | protein_coding | deleterious(0.05) | possibly_damaging(0.663) | TCGA-D8-A1JH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | nolvadex | SD | |
MED23 | SNV | Missense_Mutation | c.1715N>A | p.Val572Asp | p.V572D | Q9ULK4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E9-A1R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
MED23 | deletion | Frame_Shift_Del | c.3276_3288delGAGATTCAATGAG | p.Trp1092CysfsTer32 | p.W1092Cfs*32 | Q9ULK4 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD | |||
MED23 | insertion | Nonsense_Mutation | novel | c.2473_2474insTGTGGTCCTAGCCTTGTGAT | p.Thr825MetfsTer4 | p.T825Mfs*4 | Q9ULK4 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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