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Gene: LYZ |
Gene summary for LYZ |
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Gene information | Species | Human | Gene symbol | LYZ | Gene ID | 4069 |
Gene name | lysozyme | |
Gene Alias | LYZF1 | |
Cytomap | 12q15 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | B2R4C5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4069 | LYZ | GSM4909287 | Human | Breast | IDC | 1.71e-04 | 4.14e-01 | 0.2057 |
4069 | LYZ | NCCBC14 | Human | Breast | DCIS | 4.94e-06 | 5.54e-01 | 0.2021 |
4069 | LYZ | NCCBC3 | Human | Breast | DCIS | 5.48e-25 | 6.75e-01 | 0.1198 |
4069 | LYZ | NCCBC5 | Human | Breast | DCIS | 2.31e-05 | 5.22e-01 | 0.2046 |
4069 | LYZ | CA_HPV_1 | Human | Cervix | CC | 1.29e-31 | 1.07e+00 | 0.0264 |
4069 | LYZ | N_HPV_2 | Human | Cervix | N_HPV | 1.47e-16 | 7.15e-01 | -0.0131 |
4069 | LYZ | CCI_1 | Human | Cervix | CC | 3.79e-02 | -6.43e-01 | 0.528 |
4069 | LYZ | CCII_1 | Human | Cervix | CC | 7.61e-06 | -6.43e-01 | 0.3249 |
4069 | LYZ | Tumor | Human | Cervix | CC | 3.11e-10 | -6.23e-01 | 0.1241 |
4069 | LYZ | sample1 | Human | Cervix | CC | 1.58e-04 | -6.43e-01 | 0.0959 |
4069 | LYZ | sample3 | Human | Cervix | CC | 5.06e-10 | -6.36e-01 | 0.1387 |
4069 | LYZ | H2 | Human | Cervix | HSIL_HPV | 1.30e-16 | -7.33e-02 | 0.0632 |
4069 | LYZ | L1 | Human | Cervix | CC | 6.35e-07 | 3.17e-01 | 0.0802 |
4069 | LYZ | T1 | Human | Cervix | CC | 1.93e-09 | -6.30e-01 | 0.0918 |
4069 | LYZ | T3 | Human | Cervix | CC | 8.18e-08 | -6.30e-01 | 0.1389 |
4069 | LYZ | HTA11_78_2000001011 | Human | Colorectum | AD | 8.99e-30 | 7.39e-01 | -0.1088 |
4069 | LYZ | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.88e-08 | 2.51e-01 | -0.059 |
4069 | LYZ | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.53e-02 | 2.40e-01 | 0.0446 |
4069 | LYZ | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.40e-09 | 2.87e-01 | 0.281 |
4069 | LYZ | A002-C-010 | Human | Colorectum | FAP | 1.77e-02 | 2.98e-01 | 0.242 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001973011 | Breast | IDC | antimicrobial humoral response | 23/1434 | 122/18723 | 4.67e-05 | 1.04e-03 | 23 |
GO:000189511 | Breast | IDC | retina homeostasis | 15/1434 | 79/18723 | 8.62e-04 | 1.00e-02 | 15 |
GO:00069596 | Breast | IDC | humoral immune response | 40/1434 | 317/18723 | 1.25e-03 | 1.33e-02 | 40 |
GO:000189413 | Breast | IDC | tissue homeostasis | 34/1434 | 268/18723 | 2.54e-03 | 2.28e-02 | 34 |
GO:001973021 | Breast | DCIS | antimicrobial humoral response | 21/1390 | 122/18723 | 2.40e-04 | 3.75e-03 | 21 |
GO:000189521 | Breast | DCIS | retina homeostasis | 14/1390 | 79/18723 | 1.88e-03 | 1.81e-02 | 14 |
GO:000189423 | Breast | DCIS | tissue homeostasis | 33/1390 | 268/18723 | 2.88e-03 | 2.48e-02 | 33 |
GO:000695911 | Breast | DCIS | humoral immune response | 37/1390 | 317/18723 | 4.16e-03 | 3.29e-02 | 37 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:00197308 | Cervix | CC | antimicrobial humoral response | 27/2311 | 122/18723 | 1.70e-03 | 1.29e-02 | 27 |
GO:00019067 | Cervix | CC | cell killing | 37/2311 | 188/18723 | 2.61e-03 | 1.80e-02 | 37 |
GO:00018957 | Cervix | CC | retina homeostasis | 19/2311 | 79/18723 | 2.94e-03 | 1.94e-02 | 19 |
GO:00069597 | Cervix | CC | humoral immune response | 54/2311 | 317/18723 | 8.57e-03 | 4.42e-02 | 54 |
GO:000695912 | Cervix | HSIL_HPV | humoral immune response | 39/737 | 317/18723 | 2.88e-10 | 7.02e-08 | 39 |
GO:001973012 | Cervix | HSIL_HPV | antimicrobial humoral response | 18/737 | 122/18723 | 1.35e-06 | 6.21e-05 | 18 |
GO:000190611 | Cervix | HSIL_HPV | cell killing | 23/737 | 188/18723 | 1.45e-06 | 6.47e-05 | 23 |
GO:000189512 | Cervix | HSIL_HPV | retina homeostasis | 12/737 | 79/18723 | 5.76e-05 | 1.39e-03 | 12 |
GO:00427423 | Cervix | HSIL_HPV | defense response to bacterium | 30/737 | 350/18723 | 5.82e-05 | 1.40e-03 | 30 |
GO:000189414 | Cervix | HSIL_HPV | tissue homeostasis | 25/737 | 268/18723 | 6.17e-05 | 1.46e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049704 | Breast | IDC | Salivary secretion | 18/867 | 93/8465 | 5.69e-03 | 3.13e-02 | 2.34e-02 | 18 |
hsa0497011 | Breast | IDC | Salivary secretion | 18/867 | 93/8465 | 5.69e-03 | 3.13e-02 | 2.34e-02 | 18 |
hsa04970 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049701 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049702 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
hsa049703 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LYZ | deletion | Frame_Shift_Del | novel | c.136delN | p.Trp46GlyfsTer66 | p.W46Gfs*66 | P61626 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
LYZ | SNV | Missense_Mutation | novel | c.392N>T | p.Arg131Ile | p.R131I | P61626 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LYZ | SNV | Missense_Mutation | novel | c.283N>C | p.Cys95Arg | p.C95R | P61626 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LYZ | SNV | Missense_Mutation | novel | c.412G>T | p.Asp138Tyr | p.D138Y | P61626 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LYZ | SNV | Missense_Mutation | novel | c.206N>T | p.Ser69Ile | p.S69I | P61626 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
LYZ | SNV | Missense_Mutation | novel | c.397N>T | p.Arg133Cys | p.R133C | P61626 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
LYZ | SNV | Missense_Mutation | novel | c.397C>T | p.Arg133Cys | p.R133C | P61626 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LYZ | SNV | Missense_Mutation | novel | c.299N>A | p.Ser100Asn | p.S100N | P61626 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LYZ | SNV | Missense_Mutation | c.389G>T | p.Trp130Leu | p.W130L | P61626 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
LYZ | SNV | Missense_Mutation | novel | c.47N>A | p.Val16Asp | p.V16D | P61626 | protein_coding | deleterious(0.02) | benign(0.104) | TCGA-22-0940-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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