Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046394 | Colorectum | MSS | carboxylic acid biosynthetic process | 76/3467 | 314/18723 | 6.71e-03 | 4.38e-02 | 76 |
GO:0016053 | Colorectum | MSS | organic acid biosynthetic process | 76/3467 | 316/18723 | 7.88e-03 | 4.84e-02 | 76 |
GO:00463941 | Colorectum | MSI-H | carboxylic acid biosynthetic process | 36/1319 | 314/18723 | 2.68e-03 | 3.48e-02 | 36 |
GO:00160531 | Colorectum | MSI-H | organic acid biosynthetic process | 36/1319 | 316/18723 | 2.98e-03 | 3.78e-02 | 36 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:00160537 | Oral cavity | OSCC | organic acid biosynthetic process | 155/7305 | 316/18723 | 1.64e-04 | 1.13e-03 | 155 |
GO:00463947 | Oral cavity | OSCC | carboxylic acid biosynthetic process | 154/7305 | 314/18723 | 1.73e-04 | 1.19e-03 | 154 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LTA4H | SNV | Missense_Mutation | | c.295N>G | p.Gln99Glu | p.Q99E | P09960 | protein_coding | tolerated(0.47) | benign(0.027) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | novel | c.322N>A | p.Glu108Lys | p.E108K | P09960 | protein_coding | tolerated(0.1) | benign(0.092) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | | c.670N>C | p.Glu224Gln | p.E224Q | P09960 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | | c.1228N>A | p.Ala410Thr | p.A410T | P09960 | protein_coding | tolerated(0.07) | benign(0.194) | TCGA-AU-3779-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | | c.695C>T | p.Ala232Val | p.A232V | P09960 | protein_coding | deleterious(0.04) | benign(0.427) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | novel | c.275N>T | p.Pro92Leu | p.P92L | P09960 | protein_coding | deleterious(0.04) | possibly_damaging(0.743) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
LTA4H | SNV | Missense_Mutation | | c.523N>T | p.Arg175Cys | p.R175C | P09960 | protein_coding | deleterious(0.01) | possibly_damaging(0.832) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | novel | c.1195N>A | p.Gly399Arg | p.G399R | P09960 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LTA4H | SNV | Missense_Mutation | rs776850878 | c.1651G>A | p.Ala551Thr | p.A551T | P09960 | protein_coding | tolerated(0.3) | possibly_damaging(0.561) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
LTA4H | SNV | Missense_Mutation | novel | c.134C>A | p.Ser45Tyr | p.S45Y | P09960 | protein_coding | tolerated(0.14) | benign(0.262) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | ANTIINFLAMMATORY AGENTS | | 8423594 |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | DIPHENYLETHER | DIPHENYLETHER | 18952425 |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | montelukast | MONTELUKAST | |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 315661176 | | |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 315661187 | CHEMBL119054 | |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 178101843 | | |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | 4-PHENOXYPHENOL | CHEMBL224318 | 18952425 |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | DG051 | | |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | 4-METHOXYPHENOXYBENZENE | CHEMBL398021 | 18952425 |
4048 | LTA4H | ENZYME, DRUGGABLE GENOME, PROTEASE | | OPIOID | | 1410529 |