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Gene: KLHL8 |
Gene summary for KLHL8 |
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Gene information | Species | Human | Gene symbol | KLHL8 | Gene ID | 57563 |
Gene name | kelch like family member 8 | |
Gene Alias | KLHL8 | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B3KY78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57563 | KLHL8 | HCC1_Meng | Human | Liver | HCC | 3.11e-31 | -6.51e-03 | 0.0246 |
57563 | KLHL8 | HCC2_Meng | Human | Liver | HCC | 1.97e-05 | -8.16e-03 | 0.0107 |
57563 | KLHL8 | HCC2 | Human | Liver | HCC | 3.27e-25 | 3.42e+00 | 0.5341 |
57563 | KLHL8 | HCC5 | Human | Liver | HCC | 6.45e-11 | 9.48e-01 | 0.4932 |
57563 | KLHL8 | S028 | Human | Liver | HCC | 1.71e-07 | 3.63e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL8 | SNV | Missense_Mutation | novel | c.1067N>A | p.Arg356Lys | p.R356K | Q9P2G9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
KLHL8 | SNV | Missense_Mutation | c.785C>T | p.Pro262Leu | p.P262L | Q9P2G9 | protein_coding | deleterious(0.02) | possibly_damaging(0.589) | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLHL8 | SNV | Missense_Mutation | novel | c.1064G>A | p.Arg355Gln | p.R355Q | Q9P2G9 | protein_coding | tolerated(0.17) | benign(0.418) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLHL8 | SNV | Missense_Mutation | c.1678G>A | p.Gly560Ser | p.G560S | Q9P2G9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLHL8 | SNV | Missense_Mutation | c.325G>C | p.Glu109Gln | p.E109Q | Q9P2G9 | protein_coding | tolerated(0.32) | possibly_damaging(0.697) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLHL8 | deletion | Frame_Shift_Del | novel | c.1124delN | p.Asp375ValfsTer6 | p.D375Vfs*6 | Q9P2G9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KLHL8 | deletion | Frame_Shift_Del | novel | c.1079delN | p.Gly360ValfsTer2 | p.G360Vfs*2 | Q9P2G9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KLHL8 | SNV | Missense_Mutation | c.1763N>T | p.Ser588Phe | p.S588F | Q9P2G9 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
KLHL8 | SNV | Missense_Mutation | novel | c.958N>G | p.Leu320Val | p.L320V | Q9P2G9 | protein_coding | deleterious(0.05) | possibly_damaging(0.873) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL8 | SNV | Missense_Mutation | novel | c.169N>T | p.Leu57Phe | p.L57F | Q9P2G9 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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